Evidence map›Paper›PMID 40676019›Full record

ArticleNPJ genomic medicine2025

Serum microRNA expression quantitative trait loci in children with asthma colocalize with asthma-related GWAS results.

Julian Hecker, Anshul Tiwari, Rinku Sharma, Kevin Mendez, Jiang Li, Sofina Begum, Qingwen Chen, Albert Smith, Juan C Celedón, Scott T Weiss and 4 more

2 registry-linked trialsAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in NPJ genomic medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00000575 phase3completednot on this map

Childhood Asthma Management Program

TypeinterventionalSponsorJohns Hopkins Bloomberg School of Public HealthRan1991 to 2012Enrolled1,041ConditionsAsthma, Lung DiseasesArmsPlacebo, Nedocromil, Budesonide
NCT00021840 completednot on this map

Genetic Epidemiology of Asthma in Costa Rica

TypeobservationalSponsorBrigham and Women's HospitalRan2001 to 2011Enrolled4,245ConditionsAsthma, Lung Diseases
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Julian Hecker *Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA. rejhe@channing.harvard.edu.
Anshul Tiwari *Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN, USA.
Rinku SharmaChanning Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Kevin MendezChanning Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Jiang LiChanning Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Sofina BegumChanning Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Qingwen ChenChanning Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0002-2946-4947
Albert SmithCenter for Statistical Genetics, Department of Biostatistics, University of Michigan School of Public Health, Ann Arbor, MI, USA.
Juan C CeledónDivision of Pulmonary Medicine, Department of Pediatrics, UPMC Children's Hospital of Pittsburgh, University of Pittsburgh, Pittsburgh, PA, USA.ORCID http://orcid.org/0000-0002-6139-5320
Scott T WeissChanning Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Rachel S KellyChanning Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0003-3023-1822
Jessica A Lasky-SuChanning Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0001-6236-4705
Kelan G TantisiraDivision of Pediatric Respiratory Medicine, Department of Pediatrics, University of California San Diego, San Diego, CA, USA.
Michael McGeachieChanning Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0001-5566-2712

Funding

The Genetic Epidemiology of Asthma in Costa RicaR37HL066289 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI WEISS, SCOTT T · 2007 to 2015
$14.6M
Studies of Rare Genetic Variation in the Isolated Population of SardiniaR01HL117626 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ABECASIS, GONCALO · 2013 to 2016
$10.5M
Rare variants and NHLBI traits in deeply phenotyped cohortsR01HL120393 · NHLBI · UNIVERSITY OF WASHINGTON · PI PSATY, BRUCE M, RICE, KENNETH M. · 2014 to 2016
$8.9M
Rare variants and NHLBI traits in deeply phenotyped cohortsU01HL120393 · NHLBI · UNIVERSITY OF WASHINGTON · PI PSATY, BRUCE M, RICE, KENNETH M. · 2017 to 2018
$5.6M
Asthma Exacerbations and MicroRNA prediction: Treatment Response in an Underserved Ethnicity (AEM-TRUE)R01HL139634 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI MCGEACHIE, MICHAEL JOHN · 2018 to 2022
$4.3M
MICRORNAS IN CIRCULATION: ONTOLOGIES OF ASTHMA SEVERITY AND TREATMENT (MICROCOAST)R01HL127332 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI TANTISIRA, KELAN G · 2015 to 2018
$3.4M
Genomics and Pharmacogenomics of Symptoms in AsthmaR01HL162570 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI TANTISIRA, KELAN G · 2021 to 2024
$2.9M
Better utilization of omics data to inform precision medicine for asthma throughout the life courseR01HL169300 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI JESSICA A LASKY-SU · 2024 to 2026
$2.3M
DISEASE AND HEALTH: ASTHMA RESILIENCE THROUGH MICRORNA ATTRIBUTES (DHARMA)R01HL129935 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI TANTISIRA, KELAN G · 2015 to 2017
$1.4M
Integrating multi-omics data to understand asthma heterogeneity and endotypesK01HL169756 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI HECKER, JULIAN ERIK · 2024 to 2025
$355k
NHLBI NIH HHS HHSN268201800001CNHLBI NIH HHS K01 HL169756NHLBI NIH HHS R01 HL117626NHLBI NIH HHS R01 HL120393NHLBI NIH HHS R01 HL127332NHLBI NIH HHS R01 HL129935NHLBI NIH HHS R01 HL139634NHLBI NIH HHS R01 HL162570NHLBI NIH HHS R01 HL169300NHLBI NIH HHS R37 HL066289NHLBI NIH HHS U01 HL120393NIEHS NIH HHS HHSN268201600032CU.S. Department of Health & Human Services | NIH | National Heart, Lung, and Blood Institute (NHLBI) K01HL169756U.S. Department of Health & Human Services | NIH | National Heart, Lung, and Blood Institute (NHLBI) R01HL139634U.S. Department of Health & Human Services | NIH | National Heart, Lung, and Blood Institute (NHLBI) R01HL162570, R01HL127332, and R01HL129935
6 · The paper itself

Abstract

Asthma poses a significant public health burden. Despite identifying more than a hundred genetic risk loci in genome-wide association studies (GWAS), the underlying functional mechanisms remain poorly understood. Studying omics, especially microRNAs (miRNAs), is a promising approach to facilitate our understanding of the biological pathways of asthma. Here, we performed miRNA expression quantitative trait loci (miRNA-QTL) analyses using whole-genome sequencing and serum-based miRNA expression data from two independent cohorts of children with asthma (Genetic Epidemiology of Asthma in Costa Rica Study (GACRS), (NCT00021840, 2005-06-23) (N = 980, Discovery) and the Childhood Asthma Management Program (CAMP) (NCT00000575, 2005-06-23) (N = 354, Replication)). Our robust discovery analysis identified 28 significant cis-miRNA-QTL associations, where 12 were not reported in three independent miRNA-QTL studies. Three of these 12 signals were replicated in CAMP. The QTLs colocalize with expression and splicing QTL in asthma-relevant tissues and cells, and overlap with asthma-related and blood cell trait GWAS hits.

Identifiers

PMID40676019
PMCPMC12271466

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.