Evidence map›Paper›PMID 40676076›Full record

ArticleScientific reports2025

CAMKKβ supports growth and viability of epithelial ovarian cancer in vitro and in vivo.

Matthew J Borrelli, Adrian Buensuceso, Yudith Ramos Valdes, Tiffany P A Johnston, Jacob Haagsma, Trevor G Shepherd

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Matthew J BorrelliThe Mary and John Knight Translational Ovarian Cancer Research Unit, Verspeeten Family Cancer Centre, London, ON, N6A 5W9, Canada.
Adrian BuensucesoThe Mary and John Knight Translational Ovarian Cancer Research Unit, Verspeeten Family Cancer Centre, London, ON, N6A 5W9, Canada.
Yudith Ramos ValdesThe Mary and John Knight Translational Ovarian Cancer Research Unit, Verspeeten Family Cancer Centre, London, ON, N6A 5W9, Canada.
Tiffany P A JohnstonThe Mary and John Knight Translational Ovarian Cancer Research Unit, Verspeeten Family Cancer Centre, London, ON, N6A 5W9, Canada.
Jacob HaagsmaThe Mary and John Knight Translational Ovarian Cancer Research Unit, Verspeeten Family Cancer Centre, London, ON, N6A 5W9, Canada.
Trevor G ShepherdThe Mary and John Knight Translational Ovarian Cancer Research Unit, Verspeeten Family Cancer Centre, London, ON, N6A 5W9, Canada. trevor.shepherd@schulich.uwo.ca.

Funding

CIHR 451405Natural Sciences and Engineering Research Council of Canada PGSD3 - 560096 - 2021
6 · The paper itself

Abstract

Epithelial ovarian cancer (EOC) metastasizes predominantly through multicellular aggregates known as spheroids, which disseminate within the peritoneal cavity and initiate secondary disease upon reattachment at distant sites. EOC spheroids resist detachment-induced cell death by upregulating stress responses including AMP-activated protein kinase (AMPK) signaling and AMPK-dependent macroautophagy (autophagy), highlighting these pathways as potential therapeutic targets. Previously, we used a pharmacological approach to putatively identify Ca

Indexed as

Calcium-Calmodulin-Dependent Protein Kinase KinaseCarcinoma, Ovarian EpithelialOvarian NeoplasmsAMP-Activated Protein KinasesAnimalsAutophagyCell Line, TumorCell ProliferationCell SurvivalCRISPR-Cas SystemsFemaleGene Knockout TechniquesHumansMiceSpheroids, CellularXenograft Model Antitumor AssaysAMP-Activated Protein KinasesCalcium-Calmodulin-Dependent Protein Kinase KinaseCAMKK2 protein, humanAMPKAutophagyCAMKK2Epithelial ovarian cancerMetastasisSpheroid

Identifiers

PMID40676076
PMCPMC12271461

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.