Evidence map›Paper›PMID 40676205›Full record

ArticleLeukemia2025

Hypomethylating agents induce epigenetic and transcriptional heterogeneity with implications for acute myeloid leukemia cell self-renewal.

Danielle R Bond, Sean M Burnard, Kumar Uddipto, Kooper V Hunt, Brooke M Harvey, Luiza Steffens Reinhardt, Charley Lawlor-O'Neill, Ellise A Roper, Sam Humphries, Heather C Murray and 9 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Leukemia, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. COPD-Lung Cancer Comorbidity: Mechanistic Insights and Precision Oncology Implications.International journal of chronic obstructive pulmonary disease · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Danielle R Bond *School of Biomedical Science and Pharmacy, The University of Newcastle, Callaghan, NSW, Australia. danielle.bond@newcastle.edu.au.ORCID http://orcid.org/0000-0002-5967-0258
Sean M Burnard *School of Biomedical Science and Pharmacy, The University of Newcastle, Callaghan, NSW, Australia.ORCID http://orcid.org/0000-0003-2149-3556
Kumar UddiptoSchool of Biomedical Science and Pharmacy, The University of Newcastle, Callaghan, NSW, Australia.
Kooper V HuntSchool of Biomedical Science and Pharmacy, The University of Newcastle, Callaghan, NSW, Australia.
Brooke M HarveySchool of Biomedical Science and Pharmacy, The University of Newcastle, Callaghan, NSW, Australia.
Luiza Steffens ReinhardtSchool of Biomedical Science and Pharmacy, The University of Newcastle, Callaghan, NSW, Australia.
Charley Lawlor-O'NeillSchool of Biomedical Science and Pharmacy, The University of Newcastle, Callaghan, NSW, Australia.
Ellise A RoperSchool of Biomedical Science and Pharmacy, The University of Newcastle, Callaghan, NSW, Australia.
Sam HumphriesSchool of Biomedical Science and Pharmacy, The University of Newcastle, Callaghan, NSW, Australia.
Heather C MurraySchool of Biomedical Science and Pharmacy, The University of Newcastle, Callaghan, NSW, Australia.ORCID http://orcid.org/0000-0001-8953-3708
Abdul MannanSchool of Biomedical Science and Pharmacy, The University of Newcastle, Callaghan, NSW, Australia.
Matthew D DunSchool of Biomedical Science and Pharmacy, The University of Newcastle, Callaghan, NSW, Australia.ORCID http://orcid.org/0000-0002-9063-5370
Charles E de BockChildren's Cancer Institute, Lowy Cancer Research Centre, Randwick, NSW, Australia.ORCID http://orcid.org/0000-0001-5182-8535
Nikola A BowdenSchool of Medicine and Public Health, The University of Newcastle, Callaghan, NSW, Australia.ORCID http://orcid.org/0000-0002-6047-1694
Anoop K EnjetiPrecision Medicine Research Program, Hunter Medical Research Institute, New Lambton Heights, NSW, Australia.ORCID http://orcid.org/0000-0001-8069-090X
Nicole M VerrillsSchool of Biomedical Science and Pharmacy, The University of Newcastle, Callaghan, NSW, Australia.ORCID http://orcid.org/0000-0002-7894-0137
Carlos RiverosSchool of Medicine and Public Health, The University of Newcastle, Callaghan, NSW, Australia.ORCID http://orcid.org/0000-0002-2551-7618
Kim-Anh Lê CaoMelbourne Integrative Genomics, School of Mathematics and Statistics, The University of Melbourne, Parkville, VIC, Australia.
Heather J LeeSchool of Biomedical Science and Pharmacy, The University of Newcastle, Callaghan, NSW, Australia. Heather.lee@newcastle.edu.au.ORCID http://orcid.org/0000-0002-6482-0337

Funding

Cancer Institute NSW (Cancer Institute New South Wales) 2018/ECF001Cancer Institute NSW (Cancer Institute New South Wales) ECF1299Cure Cancer Australia Foundation (CCAF) CCAF2023-BondDepartment of Education and Training | Australian Research Council (ARC) DP200102903Department of Health | National Health and Medical Research Council (NHMRC) GNT1143614Department of Health | National Health and Medical Research Council (NHMRC) GNT1173892Department of Health | National Health and Medical Research Council (NHMRC) GNT1180782Department of Health | National Health and Medical Research Council (NHMRC) GNT2016283Hunter Medical Research Institute (HMRI) HMRI778
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Identifiers

PMID40676205
PMCPMC12380606

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.