Evidence map›Paper›PMID 40676310›Full record

ArticleClinical autonomic research : official journal of the Clinical Autonomic Research Society2025

Acetate concentration correlates with MSNA in patients with resistant hypertension.

Revathy Carnagarin, Gianni Sesa-Ashton, Natalie C Ward, Janis Nolde, Anu Joyson, Justine Chan, Ancy Jose, Markus P Schlaich

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Article in Clinical autonomic research : official journal of the Clinical Autonomic Research Society, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Revathy Carnagarin *Dobney Hypertension Centre, Medical School, Royal Perth Hospital Unit and RPH Research Foundation, The University of Western Australia, Level 3, MRF Building, 50 Rear Murray Street, Perth, WA, 6000, Australia.
Gianni Sesa-Ashton *Cardiometabolic Health and Exercise Physiology Laboratory, Baker Heart and Diabetes Institute, Melbourne, Australia.
Natalie C WardDobney Hypertension Centre, Medical School, Royal Perth Hospital Unit and RPH Research Foundation, The University of Western Australia, Level 3, MRF Building, 50 Rear Murray Street, Perth, WA, 6000, Australia.
Janis NoldeDobney Hypertension Centre, Medical School, Royal Perth Hospital Unit and RPH Research Foundation, The University of Western Australia, Level 3, MRF Building, 50 Rear Murray Street, Perth, WA, 6000, Australia.
Anu JoysonDobney Hypertension Centre, Medical School, Royal Perth Hospital Unit and RPH Research Foundation, The University of Western Australia, Level 3, MRF Building, 50 Rear Murray Street, Perth, WA, 6000, Australia.
Justine ChanDobney Hypertension Centre, Medical School, Royal Perth Hospital Unit and RPH Research Foundation, The University of Western Australia, Level 3, MRF Building, 50 Rear Murray Street, Perth, WA, 6000, Australia.
Ancy JoseDobney Hypertension Centre, Medical School, Royal Perth Hospital Unit and RPH Research Foundation, The University of Western Australia, Level 3, MRF Building, 50 Rear Murray Street, Perth, WA, 6000, Australia.
Markus P SchlaichDobney Hypertension Centre, Medical School, Royal Perth Hospital Unit and RPH Research Foundation, The University of Western Australia, Level 3, MRF Building, 50 Rear Murray Street, Perth, WA, 6000, Australia. markus.schlaich@uwa.edu.au.ORCID http://orcid.org/0000-0002-1765-0195

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeShort-chain fatty acids (SCFAs), metabolites of colonic microflora fermentation of dietary fibre, have been implicated in experimental models and clinical trials to impact blood pressure (BP) regulation. Dietary interventions increasing serum SCFA levels have been associated with reduced 24-h systolic BP in hypertensive patients. However, the underlying mechanisms remain elusive. Given the role of the gut-brain axis and clear evidence for sympathetic nervous system activation as important modulators of blood pressure, we examined the relationship between sympathetic drive and SCFA concentration in patients with resistant hypertension (RH) and healthy control subjects (HC).

methodsA total of 21 patients with RH (68.6 ± 9.7 years, 47% male) and 28 healthy control subjects (HC) (34.6 ± 16.7 years, 75% male) were recruited to undergo microneurography for determination of muscle sympathetic nerve activity (MSNA), automated office BP (AOBP) and blood collection for serum SCFA.

resultsMean systolic AOBP was 156 ± 21 mmHg and 115 ± 10 mmHg for RH and HC, respectively (p < 0.0001). Serum acetate levels were 1340 ± 115.4 umol/L for HC and 724.5 ± 116.9 umol/L for RH (p < 0.0001). Butyrate and propionate concentrations did not significantly differ between groups. MSNA burst frequency was markedly elevated in RH compared with HCs (p < 0.001), with 25.3 ± 7.4 burst/minute in HC compared with 40.24 ± 8.3 burst/minute in RH. An inverse relationship was evident between serum acetate levels and MSNA burst frequency (p = 0.0267, R

conclusionsOur findings suggest that the beneficial effects of SCFA levels, in particular acetate, on cardiovascular regulation may at least in part be mediated by sympatho-inhibition and altered sympathetic vascular transduction.

Indexed as

AcetatesHypertensionSympathetic Nervous SystemAdultAgedBlood PressureFemaleHumansMaleMiddle AgedAcetatesMicroneurographyResistant hypertensionShort-chain fatty acidsSympathetic nervous system

Identifiers

PMID40676310
PMCPMC12664844

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.