ReviewMolecular neurobiology2025
Mechanisms of Alcohol Interference with Hippocampal Neurogenesis and its Repair Strategies.
Review in Molecular neurobiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
The hippocampus is the central target of alcohol-induced neurotoxicity in impairing memory function, with neurogenesis inhibition being its primary mechanism of action. Alcohol interference with hippocampal neurogenesis is closely associated with various diseases. However, limited treatment options currently exist for alcohol-induced hippocampal neuronal damage, and the therapeutic effects are unsatisfactory, placing a significant economic and mental burden on patients' families and society. This review summarises the effects of alcohol on hippocampal neurogenesis during the foetal, adolescent, and adult periods, as well as its mechanisms of action. During the foetal period, alcohol exposure may lead to a decrease in hippocampal cell numbers, impairment of hippocampal synaptic plasticity, alterations in neurodevelopmental proteins, reduced expression of various receptors, interference with neural stem cell differentiation, changes in hippocampal DNA methylation, modifications in neurotrophic factor levels, induction of neuroinflammatory responses, and slow ethanol metabolism. In adolescence, alcohol consumption can adversely affect hippocampal neurogenesis and synapse formation, disrupt metabolic processes within the hippocampus, trigger inflammatory responses, and impair the synthesis of neurotrophic factors. During adulthood, alcohol intake may lead to a reduction in hippocampal neurogenesis, and provoke neuroinflammatory responses, suppress the expression of neurotrophic factors, alter hippocampal metabolite levels, and impact cytoskeletal dynamics within the hippocampus. We also explore potential repair strategies, including pharmacological treatments, nutritional supplementation, plant extracts, and physical therapy, to promote more effective therapeutic approaches.
Indexed as
Identifiers
40676366What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.