ArticleCardiovascular toxicology2025
Dose-Dependent Effects of Subchronic Lead Exposure on the Right Atrium and Right Ventricle of Rats: An In Vitro Investigation.
Article in Cardiovascular toxicology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Molecular Mechanisms of Effects of Lead and Cadmium Co-exposure on Atrial and Ventricular Myocardium: Soluble Salts Versus Nanoparticles.Cardiovascular toxicology · 2026Article
Corrections and comments
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Authors and funding
13 authors.
Funding
Abstract
Lead poisoning remains a significant threat to both human and animal health, with cardiovascular dysfunction being one of its primary adverse effects. This study aimed to investigate the function of the right atrium and right ventricle in 12-month-old male rats exposed to 5.5, 11, and 22.88 mg/kg body weight of lead acetate, injected intraperitoneally three times a week for six weeks. Lead exposure resulted in a reduction in blood pressure (11 mg/kg b.w.) and QRS amplitude, and a lowering of the isoelectric line. Lead exposure led to a dose-dependent shift in the myosin heavy chain (MHC) ratio toward the slower β-MHC isoform in the right ventricle, whereas no changes were detected in the right atrium. We observed a dose-dependent increase in myosin regulatory light chain phosphorylation in the right ventricle and a decrease in the right atrium. In the atria, both active and passive tensions were reduced, while no significant alterations were found in the right ventricle. However, a dose-dependent slowing of the action potential was found in both atrial and ventricular myocardium. Both the right atrium and right ventricle demonstrated responses to lead exposure; however, there was a mismatch between the alterations observed in atrial and ventricular parameters. These findings suggest that the atrial and ventricular myocardium adapt differently to lead exposure, with their responses varying depending on the specific dosage of lead consumed.
Indexed as
Identifiers
40676397What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.