Evidence map›Paper›PMID 40676474›Full record

ArticleStem cell reviews and reports2025

Tissue-Resident Mesenchymal Stem/stromal Cells (MSC) Modulate the Angiogenic Processes in Brain Arteriovenous Malformations (bAVM).

Claudia Alexandra Dumitru, Belal Neyazi, Tamer Ayberk Kaya, Klaus-Peter Stein, Ali Rashidi, Christian Mawrin, Ibrahim Erol Sandalcioglu

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Article in Stem cell reviews and reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Claudia Alexandra DumitruDepartment of Neurosurgery, Otto-von-Guericke University, Magdeburg, Germany. claudia.dumitru@med.ovgu.de.ORCID 0000-0003-2075-9164
Belal NeyaziDepartment of Neurosurgery, Otto-von-Guericke University, Magdeburg, Germany.
Tamer Ayberk KayaDepartment of Neurosurgery, Otto-von-Guericke University, Magdeburg, Germany.
Klaus-Peter SteinDepartment of Neurosurgery, Otto-von-Guericke University, Magdeburg, Germany.
Ali RashidiDepartment of Neurosurgery, Otto-von-Guericke University, Magdeburg, Germany.
Christian MawrinDepartment of Neuropathology, Otto-von-Guericke University, Magdeburg, Germany.
Ibrahim Erol SandalciogluDepartment of Neurosurgery, Otto-von-Guericke University, Magdeburg, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMesenchymal stem/stromal cells (MSCs) have been mainly studied in the context of cell-based therapy for a variety of medical conditions, including cerebrovascular diseases. However, the role of tissue-resident MSCs in the pathophysiology of cerebrovascular diseases in general and of brain arteriovenous malformation (bAVM) in particular is currently unknown, and was investigated in this study.

methodsHuman bAVM tissues were used to identify MSCs in situ (n = 10) and to isolate them ex vivo (n = 3). The paracrine effects of bAVM-MSCs on endothelial cells (ECs) were assessed in an ex vivo model using MSC-derived supernatants (SNs) and the EC line HUVEC. Selected functional assays were validated using a second EC line (HCAEC).

resultsIn situ, cells with a MSC-like phenotype (CD90

conclusionsThese findings indicate that bAVMs contain tissue-resident MSCs, which can potentially modulate the biology and functions of the ECs in the bAVM microenvironment. Thus, MSCs may play critical roles in the pathophysiology and the progression of this disease.

Indexed as

Intracranial Arteriovenous MalformationsMesenchymal Stem CellsNeovascularization, PathologicNeovascularization, PhysiologicAdultCell MovementCell ProliferationEndothelial CellsFemaleHumansHuman Umbilical Vein Endothelial CellsMaleMiddle AgedAngiogenesisBrain arteriovenous malformationsEndothelial-to-mesenchymal transitionMesenchymal stem/stromal cells

Identifiers

PMID40676474
PMCPMC12408775

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.