Evidence map›Paper›PMID 40676501›Full record

ReviewThe journal of headache and pain2025

Hallmarks of primary headache: part 2- Tension-type headache.

Li-Ling Hope Pan, Yu-Hsiang Ling, Shuu-Jiun Wang, Linda Al-Hassany, Wei-Ta Chen, Chia-Chun Chiang, Soo-Jin Cho, Min Kyung Chu, Gianluca Coppola, Adriana Della Pietra and 30 more

Registry-linked trialAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in The journal of headache and pain, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07779655 (Tension-type Headache and Its Association With Smartphone Use,Sleep Quality and Quality of Life), which is not on this map. Cited by 25 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07779655 not yet recruitingnot on this mapstarted 2026, after this paper: background citation

Tension-type Headache and Its Association With Smartphone Use,Sleep Quality and Quality of Life

TypeobservationalSponsorAssiut UniversityRan2026 to 2028Enrolled199ConditionsTension-Type Headache, Sleep Disturbance, Smartphone Addiction, Quality of Life
3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 3 syntheses or guidelines pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

40 authors.

Li-Ling Hope Pan *Brain Research Center, National Yang Ming Chiao Tung University, Taipei, Taiwan.
Yu-Hsiang Ling *Department of Neurology, Neurological Institute, Taipei Veterans General Hospital, Taipei, Taiwan.
Shuu-Jiun Wang *Brain Research Center, National Yang Ming Chiao Tung University, Taipei, Taiwan. sjwang@vghtpe.gov.tw.ORCID 0000-0001-5179-5358
Linda Al-HassanyDepartment of Internal Medicine, Division of Vascular Medicine and Pharmacology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands.
Wei-Ta ChenDepartment of Neurology, Neurological Institute, Taipei Veterans General Hospital, Taipei, Taiwan.
Chia-Chun ChiangDepartment of Neurology, Mayo Clinic, Rochester, MN, USA.
Soo-Jin ChoDepartment of Neurology, Dongtan Sacred Heart Hospital, Hallym University College of Medicine, Hwaseong, Republic of Korea.
Min Kyung ChuDepartment of Neurology, Yonsei University College of Medicine, Seoul, Republic of Korea.
Gianluca CoppolaDepartment of Medico-Surgical Sciences and Biotechnologies, Sapienza University of Rome Polo Pontino ICOT, Latina, Italy.
Adriana Della PietraDepartment of Molecular Physiology and Biophysics, Carver College of Medicine, University of Iowa, Iowa City, IA, USA.
Zhao DongDepartment of Neurology, The First Medical Center of Chinese PLA General Hospital, Beijing, China.
Esme EkizogluDepartment of Neurology, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey.
Charl ElsDepartment of Medicine, Division of Preventive Medicine, Faculty of Medicine and Dentistry, University of Alberta, University of Alberta, Edmonton, AB, Canada.
Fatemeh FarhamHeadache department, Iranian center of Neurological researchs, Neuroscience Institute, Tehran university of Medical Sciences, Tehran, Iran.
David Garcia-AzorinDepartment of Neurology, Hospital Universitario Rio Hortega, Valladolid, Spain.
Woo-Seok HaDepartment of Neurology, Yonsei University College of Medicine, Seoul, Republic of Korea.
Fu-Jung HsiaoBrain Research Center, National Yang Ming Chiao Tung University, Taipei, Taiwan.
Ryotaro IshiiDepartment of Neurology, Kyoto Prefectural University of Medicine, Kyoto, Japan.
Byung-Kun KimDepartment of Neurology, Nowon Eulji Medical Center, Eulji University School of Medicine, Seoul, South Korea.
Najib KissaniNeurology Department, Mohammed VI University Hospital Center of Marrakech, Marrakech, MAR, Morocco.
Alejandro Labastida-RamirezDivision of Neuroscience, Faculty of Biology, Medicine, and Health, University of Manchester, Manchester, UK.
Kristin Sophie LangeDepartment of Neurology, Charité- Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.
Ellina LytvyakDepartment of Medicine, Division of Preventive Medicine, Faculty of Medicine and Dentistry, University of Alberta, University of Alberta, Edmonton, AB, Canada.
Dilara OnanDepartment of Physiotherapy and Rehabilitation, Faculty of Heath Sciences, Yozgat Bozok University, Yozgat, Turkey.
Aynur OzgeProfessor of Neurology, Headache Clinic, Mersin, Turkey.
Laura PapettiDevelopmental Neurology Unit, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.
Lanfranco PellesiDepartment of Public Health, Clinical Pharmacology, Pharmacy and Environmental Medicine, University of Southern Denmark, Odense, Denmark.
Bianca RaffaelliDepartment of Neurology, Charité- Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.
Alberto RaggiNeurology, Public Health and Disability Unit, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy.
Sebastian StraubeDepartment of Medicine, Division of Preventive Medicine, Faculty of Medicine and Dentistry, University of Alberta, University of Alberta, Edmonton, AB, Canada.
Tsubasa TakizawaDepartment of Neurology, Keio University School of Medicine, Tokyo, Japan.
Surat TanprawateChiang Mai University, Chiang Mai, Thailand.
Derya Uğurlu UludüzDepartment of Neurology, Istanbul Cerrahpasa University Medical Faculty, Istanbul, Turkey.
Kiratikorn VongvaivanichNeuroscience center, Bangkok International Hospital, BDMS, Bangkok, Thailand.
Marta Waliszewska-ProsółNeurology, Wroclaw Medical University, Wroclaw, Poland.
Yonggang WangDepartment of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Tissa WijeratneDepartment of Neurology, Sunshine Hospital, Western Health, VIC, St Albans, Australia.
Jr-Wei WuDepartment of Neurology, Neurological Institute, Taipei Veterans General Hospital, Taipei, Taiwan.
Sophie Merve YenerMigraine Foundation Australia, Melbourne, VIC, Australia.
Paolo Martelletti *School of Health, Unitelma Sapienza University of Rome, Rome, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

aimTension-type headache is the most prevalent primary headache disorder. While the episodic subtype is more common, chronic tension-type headache significantly impacts health-related quality of life and contribute to increased healthcare utilization and disability. Despite considerable advances in the understanding of tension-type headache, critical gaps persist. This paper aims to provide a comprehensive review of the hallmarks of tension-type headache, from its pathophysiology, comorbidities, treatment options, to psychosocial impact. MAIN

resultsMultiple factors are associated with tension-type headache, including peripheral mechanisms (increased muscle tenderness and myofascial trigger points), central sensitization, genetic predisposition, and psychological comorbidities such as anxiety and depression. Neuroimaging and neurophysiological studies demonstrated altered pain processing in cortical and subcortical regions in patients with tension-type headache. Regarding treatment strategy, in addition to pharmacological treatment, novel insights into non-pharmacological interventions such as cognitive behavioral therapy, neuromodulation techniques, physical therapy, mindfulness, lifestyle management, and patient education were highlighted as valuable components of comprehensive management strategies.

conclusionsA complex interplay between peripheral and central mechanisms and psychosocial stressors underpins tension-type headache. Integrated multidisciplinary approaches combining pharmacological and non-pharmacological interventions are critical for optimal patient outcomes. Further research should continue to refine the understanding of these mechanisms to improve targeted therapeutic strategies and reduce the global burden of tension-type headache.

Indexed as

Tension-Type HeadacheHumansDisease burdenNon-pharmacological treatmentsPrimary headacheTension-type headache

Identifiers

PMID40676501
PMCPMC12273213

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.