Evidence map›Paper›PMID 40676525›Full record

ArticleBMC gastroenterology2025

Platelet-derived growth factor receptor-β as a non-invasive biomarker for liver fibrosis prediction in Egyptian diabetic patients with metabolic-associated fatty liver disease.

Hanaa Badran, Maha Elsabaawy, Mai Magdy, Hazem Omar, Olfat Hendy, Eman Awaad, Maymona Abd El-Wahed Al-Khalifa, Mai Abozeid

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Article in BMC gastroenterology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Hanaa BadranHepatology and Gastroenterology Department, National Liver Institute, Menoufia University, Shebin El-Kom, Menoufia, 32511, Egypt.
Maha ElsabaawyHepatology and Gastroenterology Department, National Liver Institute, Menoufia University, Shebin El-Kom, Menoufia, 32511, Egypt.
Mai MagdyHepatology and Gastroenterology Department, National Liver Institute, Menoufia University, Shebin El-Kom, Menoufia, 32511, Egypt.
Hazem OmarDiagnostic and Interventional Radiology and Medical Imaging Department, National Liver Institute, Menoufia University, Shebin El-Kom, Menoufia, Egypt.
Olfat HendyClinical and Chemical Pathology Department, National Liver institute, Menoufia University, Shebin El-Kom, Menoufia, Egypt.
Eman AwaadAnesthesiology and ICU Department, National Liver institute, Menoufia University, Shebin El-Kom, Menoufia, Egypt.
Maymona Abd El-Wahed Al-KhalifaFellow Lecturer in Therapeutic Nutrition Department, National Liver institute, Menoufia University, Shebin El-Kom, Menoufia, Egypt.
Mai AbozeidHepatology and Gastroenterology Department, National Liver Institute, Menoufia University, Shebin El-Kom, Menoufia, 32511, Egypt. dr.maiabozeid@gmail.com.ORCID https://orcid.org/0000-0003-1808-7928

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCirculating platelet-derived growth factor receptor-β (PDGFRβ) has recently been found to correlate with severity of liver disease in multiple etiologies, including liver steatosis. In diabetic patients with metabolic-associated fatty liver disease (MAFLD), widely used non-invasive scoring systems, particularly the fibrosis-4 (FIB-4) score, showed unsatisfactory performance in predicting liver fibrosis severity. The aim of this study was to evaluate the productivity of serum PDGFRβ as a non-invasive biomarker of liver fibrosis in diabetic MAFLD patients.

methodsThis was a population-based case-control study conducted on 50 diabetic MAFLD patients, 40 nondiabetic MAFLD patients, and 40 healthy controls. All subjects underwent complete history taking, clinical examination, anthropometric measurements, bioelectrical impedance analysis (BIA), and laboratory tests, including the PDGFRβ assay. Hepatic steatosis was assessed with magnetic resonance imaging (MRI), along with magnetic resonance elastography (MRE) for the assessment of liver fibrosis. The diagnostic performance of PDGFRβ as well as PDGFRβ + FIB-4 in prediction of significant liver fibrosis in diabetic MAFLD patients was assessed.

resultsLiver steatosis and significant liver fibrosis (≥ F2) were significantly higher in diabetic MAFLD patients than in nondiabetics. PDGFRβ levels were significantly higher in both diabetic and nondiabetic MAFLD patients compared to controls. Sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) of PDGFRβ to predict significant liver fibrosis in diabetic MAFLD patients were 85%, 93.33%, 89.5%, and 90.3%, respectively, at a cutoff > 2.54, and were 85.71%, 51.52%, 27.3%, and 94.4% at a cutoff > 1.59 in nondiabetics. Sensitivity, specificity, PPV, and NPV of (PDGFRβ at a cutoff > 2.54 + FIB-4 at a cutoff > 1.17) to predict significant liver fibrosis in diabetic MAFLD patients were 100%. PDGFRβ was the only independent predictor of significant liver fibrosis in diabetic MAFLD (p = 0.006).

conclusionsPDGFRβ proved efficacy as a noninvasive biomarker in the prediction of significant liver fibrosis (≥ F2) in diabetic MAFLD patients.

Indexed as

Diabetes ComplicationsFatty LiverLiver CirrhosisReceptor, Platelet-Derived Growth Factor betaAdultBiomarkersCase-Control StudiesEgyptElasticity Imaging TechniquesFemaleHumansMagnetic Resonance ImagingMaleMiddle AgedPredictive Value of TestsSeverity of Illness IndexBiomarkersReceptor, Platelet-Derived Growth Factor betaDiabetes mellitusLiver fibrosisMAFLDPDGFRβ

Identifiers

PMID40676525
PMCPMC12272993

What Socratic holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.