Evidence map›Paper›PMID 40676569›Full record

ArticleBMC neurology2025

Faciobrachial dystonic seizure can be triggered by swallowing in LGI1 encephalitis.

Wendeng Xu, Wei Zhang, Xiaofeng Zhang

Abstract readCase Reports
In one paragraph

Article in BMC neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Wendeng XuDepartment of Neurology, Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua Medicine, Tsinghua University, Beijing, 102218, China.
Wei ZhangDepartment of Neurology, Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua Medicine, Tsinghua University, Beijing, 102218, China. zhangwei501@163.com.
Xiaofeng ZhangDepartment of Neurology, Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua Medicine, Tsinghua University, Beijing, 102218, China. zxfa02279@btch.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundLeucine-rich glioma inactivated 1 (LGI1) antibodies are associated with a limbic encephalitis syndrome characterized by faciobrachial dystonic seizures (FBDSs) that is responsive to immunotherapy. The precise pathophysiology, neural origins, and underlying mechanisms of FBDS remain incompletely understood. CASE REPORT: We present a 54-year-old Chinese female patient with LGI1-related isolated FBDS triggered by swallowing. DISCUSSION: FBDS in LGI1-antibody encephalitis exhibit overlapping features with both paroxysmal kinesigenic dyskinesia (PKD) and epileptic motor seizures, both in their clinical manifestations and underlying neural mechanisms. This unique intersection suggests that FBDS represents a pathophysiological borderland between epileptic motor seizures and paroxysmal movement disorders, bridging the gap between these two diagnostic categories.

conclusionFBDS triggered by swallowing expands the clinical spectrum of FBDS and provides new insights into its potential reflex mechanisms, offering a valuable insight for future research into its pathophysiology.

Indexed as

DeglutitionEncephalitisLimbic EncephalitisSeizuresAutoantibodiesFemaleHumansIntracellular Signaling Peptides and ProteinsMiddle AgedAutoantibodiesIntracellular Signaling Peptides and ProteinsLGI1 protein, humanEncephalitisFBDSLGI1 antibody

Identifiers

PMID40676569
PMCPMC12273332

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.