Evidence map›Paper›PMID 40676664›Full record

ArticleJournal of animal science and biotechnology2025

Effect of increasing dietary isoacid levels on total tract and apparent ileal nutrient digestibility and fermentation products in growing pigs fed corn-soybean meal diets.

Angie P Benavides-Infante, Lucas A Rodrigues, Mike T Socha, Wesley P Schweer, Crystal L Levesque, Jorge Y Perez-Palencia

Abstract read
In one paragraph

Article in Journal of animal science and biotechnology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Angie P Benavides-InfanteDepartment of Animal Science, South Dakota State University, 1097 North Campus Drive, Brookings, SD, 57007, USA.
Lucas A RodriguesZinpro Corporation, Eden Prairie, MN, 55344, USA.
Mike T SochaZinpro Corporation, Eden Prairie, MN, 55344, USA.
Wesley P SchweerZinpro Corporation, Eden Prairie, MN, 55344, USA.
Crystal L LevesqueDepartment of Animal Science, South Dakota State University, 1097 North Campus Drive, Brookings, SD, 57007, USA.
Jorge Y Perez-PalenciaDepartment of Animal Science, South Dakota State University, 1097 North Campus Drive, Brookings, SD, 57007, USA. jorgeyair1@hotmail.com.

Funding

Zinpro SA2300029
6 · The paper itself

Abstract

backgroundIsoacids are the product of branched-chain amino acid fermentation and are naturally produced in the hindgut by microbial fermentation. In ruminants, supplementation of isoacids as a feed additive improves fiber utilization, with a positive impact on animal productivity. However, information on how isoacids impact nutrient digestibility in swine is limited. The objective of this experiment was to determine the optimal inclusion level of an isoacid blend product based on apparent ileal digestibility (AID) and apparent total tract digestibility (ATTD) of nutrients and fermentation products in the ileal digesta and feces of growing pigs fed a corn-soybean meal diet.

methodsTwelve ileal cannulated pigs (20.9 ± 0.6 kg) were used in a 5-period crossover design with 6 diets and 2 replicate pigs in each period. Dietary treatments consisted of increasing levels (0%, 0.5%, 0.75%, 1%, 1.25%, and 1.5%) of an isoacid blend (isobutyrate, isovalerate, and 2-methyl butyrate, 1:1:1) added to a corn-soybean meal basal diet. Each experimental period consisted of 14 d: 10 d for acclimatization to the diets, 2 d for fecal collection, and 2 d for digesta collection.

resultsIsoacids supplementation quadratically improved the AID of hemicellulose (P < 0.05) and tended to improve the AID of crude fiber (P < 0.1). The AID of most indispensable amino acids (except Met + Cys, Trp, and Val) as well as the ATTD of crude protein, gross energy, neutral detergent fiber, and hemicellulose improved or tended to improve linear or quadratically (P < 0.05 or P < 0.1). In addition, the ATTD values of Arg, His, Ile, Leu, Met + Cys, Phe, Thr, and Val increased quadratically (P < 0.05). Collectively, 1% of isoacids inclusion resulted in the greatest response. Furthermore, isoacids supplementation tended to increase (P = 0.071, quadratically) the concentration of ammonia and decreased (P < 0.05) the concentrations of acetic acid and total volatile fatty acids with a tendency to decrease (P = 0.064) isovaleric acid in the ileal digesta. In fecal samples, the proportion of acetic acid decreased (P < 0.05) quadratically, whereas the proportions of propionic, valeric, and caproic acids tended to increase linearly and/or quadratically (P < 0.1).

conclusionsIsoacids supplementation at 1% in swine diets can improve nutrient digestibility, particularly amino acids and fiber at the ileal level and ATTD of crude protein, gross energy, and hemicellulose.

Indexed as

Branched-chain fatty acidsDietary fiberFeed additivesIsobutyrateIsovalerateVolatile fatty acid

Identifiers

PMID40676664
PMCPMC12272956

What Socratic holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.