ArticleBiochemical Society transactions2025
The fantastic voyage: primordial germ cell migration through the developing mouse embryo.
Article in Biochemical Society transactions, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Article
- Unravelling Multilayered RNA Modification Networks in Female Reproduction and Obstetric/Gynaecologic Disorders.Biomolecules · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
During the early stages of embryonic development, a small population of cells is set aside to form the germline. These primordial germ cells (PGCs) are often specified separate in time and space from their eventual home, the developing gonads. PGCs must therefore undertake a journey through the developing tissues of the embryo to reach their destination and ensure the fertility of the organism. Despite decades of interest in this topic and significant progress made in other model organisms, there is still very little known about how this migration is accomplished in the mouse or any other mammal. In this review, I explore over half a century of work examining this enigmatic cell and its voyage through the mouse embryo, interpreting these findings in light of recent discoveries in the field of cell migration. I discuss possible migration modes used by mouse PGCs, changes in their microenvironment that could influence migration, and roles the nucleus might play in their journey. With modern advances in microscopy and transgenic reporter mice, it is time to delve into this fascinating and important model of cell migration in vivo.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.