Evidence map›Paper›PMID 40676968›Full record

ArticleHistology and histopathology2026

Resveratrol attenuates hepatic inflammation and oxidative stress in collagen-induced arthritis (CIA) mice via the Nrf2/Keap1 pathway.

Xuefei Fan, Suhuan Chen, Haomiao Liu, Nannan Liu, Mengyan Zhang, Mengmeng Chen, Wuqi Chen, Guangyi Chen, Weilu Gao, Tao Yao and 1 more

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Article in Histology and histopathology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

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5 · Who and what money

Authors and funding

11 authors.

Xuefei Fan *Department of Histology and Embryology, Anhui Medical University, Hefei, Anhui Province, PR China.
Suhuan Chen *Department of Histology and Embryology, Anhui Medical University, Hefei, Anhui Province, PR China.
Haomiao Liu *Department of Orthopedics and Joint Surgery, the First Affiliated Hospital of Anhui Medical University, Hefei, Anhui Province, PR China.
Nannan LiuDepartment of Histology and Embryology, Anhui Medical University, Hefei, Anhui Province, PR China.
Mengyan ZhangDepartment of Histology and Embryology, Anhui Medical University, Hefei, Anhui Province, PR China.
Mengmeng ChenDepartment of Histology and Embryology, Anhui Medical University, Hefei, Anhui Province, PR China.
Wuqi ChenDepartment of Histology and Embryology, Anhui Medical University, Hefei, Anhui Province, PR China.
Guangyi ChenDepartment of Histology and Embryology, Anhui Medical University, Hefei, Anhui Province, PR China.
Weilu GaoDepartment of Orthopedics and Joint Surgery, the First Affiliated Hospital of Anhui Medical University, Hefei, Anhui Province, PR China.
Tao YaoDepartment of Orthopedics, The Third Affiliated Hospital of Anhui Medical University, The First People's Hospital of Hefei, Hefei, Anhui Province, PR China. 3093435182@qq.com.
Xiaoyu ChenDepartment of Histology and Embryology, Anhui Medical University, Hefei, Anhui Province, PR China. cxyayd@163.com.

Funding

Basic and Clinical Cooperative Research Promotion Program of the Third Affiliated Hospital of Anhui Medical University 2022sfy010
6 · The paper itself

Abstract

backgroundRheumatoid arthritis can affect extra-articular organs such as the liver, and the problem of drug-induced liver injury caused by traditional antirheumatic drugs for improving the condition cannot be ignored. This study aims to investigate the therapeutic effects of resveratrol (Res) on hepatic inflammation and oxidative stress in mice with collagen-induced arthritis (CIA) and to elucidate the relationship between the regulatory mechanisms of the nuclear factor erythroid 2-related factor 2 (Nrf2)/Kelch-like ECH-associated protein 1 (Keap1) signaling pathway.

methodsIn this study, we used chicken type II collagen in combination with complete Freund's adjuvant to induce arthritis in a mouse model, and Res was administered by tube feeding to detect the serum biochemical liver function and inflammation levels, oxidative stress, and apoptosis in the livers of mice. An

resultsRes significantly reduced the levels of inflammation and oxidative stress in liver tissues of CIA mice as well as in MPHs treated with TNF-α and H

conclusionThis study demonstrated the intrinsic mechanism of Res of attenuating hepatic inflammation and oxidative stress in CIA mice through the Nrf2/Keap1 pathway, which provides a new idea for finding hepatoprotective treatments for rheumatoid arthritis.

Indexed as

AntioxidantsArthritis, ExperimentalKelch-Like ECH-Associated Protein 1NF-E2-Related Factor 2Oxidative StressResveratrolAnimalsApoptosisHepatocytesInflammationLiverMaleMiceMice, Inbred DBASignal TransductionAntioxidantsKeap1 protein, mouseKelch-Like ECH-Associated Protein 1Nfe2l2 protein, mouseNF-E2-Related Factor 2Resveratrol

Identifiers

PMID40676968

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.