Evidence map›Paper›PMID 40677003›Full record

ArticleJournal of hospital medicine2026

Supportive noninvasive ventilation for acute chest syndrome prevention in hospitalized children with sickle cell disease: Determinants of implementation.

Shana A Burrowes, Kayla C Jones, Christopher J Williams, Caitlin M Neri, Elizabeth S Klings, Scarlett L Bellamy, Allan J Walkey, Mari-Lynn Drainoni, Robyn T Cohen

Abstract read
In one paragraph

Article in Journal of hospital medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Shana A BurrowesSection of Infectious Diseases, Department of Medicine, Boston University Chobanian and Avedisian School of Medicine, Boston, Massachusetts, USA.
Kayla C JonesDepartment of Medicine, Evans Center for Implementation and Improvement Sciences, Boston University Chobanian and Avedisian School of Medicine, Boston, Massachusetts, USA.ORCID https://orcid.org/0000-0002-5902-159X
Christopher J WilliamsBoston University Chobanian and Avedisian School of Medicine, Boston, Massachusetts, USA.ORCID https://orcid.org/0000-0002-9214-2238
Caitlin M NeriDepartment of Pediatrics, Boston Medical Center, Boston, Massachusetts, USA.ORCID https://orcid.org/0000-0001-7606-181X
Elizabeth S KlingsCenter of Excellence in Sickle Cell Disease, Boston University Chobanian and Avedisian School of Medicine, Boston, Massachusetts, USA.ORCID https://orcid.org/0000-0001-6857-6207
Scarlett L BellamyDepartment of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, USA.ORCID https://orcid.org/0000-0002-2906-4046
Allan J WalkeyDepartment of Medicine, Division of Health Systems Science, University of Massachusetts Chan Medical School, Worcester, Massachusetts, USA.ORCID https://orcid.org/0000-0003-4685-6894
Mari-Lynn DrainoniSection of Infectious Diseases, Department of Medicine, Boston University Chobanian and Avedisian School of Medicine, Boston, Massachusetts, USA.ORCID https://orcid.org/0000-0001-7214-8037
Robyn T CohenDepartment of Pediatrics, Boston Medical Center, Boston, Massachusetts, USA.ORCID https://orcid.org/0000-0002-6902-3118

Funding

Project-005UL1TR001430 · NCATS · BOSTON UNIVERSITY MEDICAL CAMPUS · PI BAIR-MERRITT, MEGAN H, CENTER, DAVID M. · 2015 to 2024
$52.3M
1/2 Sickle Cell Disease and CardiovAscular Risk - Red cell Exchange Trial (SCD-CARRE Trial)UG3HL143192 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI GLADWIN, MARK T, TRIULZI, DARRELL J · 2019 to 2019
$1.5M
NCATS NIH HHS 1UL1TR001430NCATS NIH HHS UL1 TR001430NHLBI NIH HHS UG3 HL143192
6 · The paper itself

Abstract

backgroundIn 2017 Boston Medical Center's (BMC) general pediatric inpatient unit implemented bi-level positive airway pressure (BiPAP) as supportive noninvasive ventilation for acute chest syndrome prevention (SNAP) to prevent adverse respiratory outcomes among medically stable, hospitalized patients with sickle cell disease. Barriers and facilitators to SNAP implementation at BMC differ from those in other settings.

objectiveTo examine contextual determinants of SNAP implementation across different settings.

methodsWe conducted semi-structured interviews with inpatient clinicians at three sites (Site 1: extensive implementation, Site 2: limited implementation, Site 3: not implemented) about factors that would affect SNAP implementation. Interviews and analysis were guided by the Promoting Action on Research Implementation in Health Services (PARiHS) framework.

resultsWe interviewed 29 healthcare workers (physicians, nurses, physician assistants, child life specialists, respiratory therapists and psychologists). Five major themes emerged: (1) Communication between staff, particularly between the night and day shift, is critical for BiPAP initiation and success. (2) Nurses are key to successful SNAP implementation. (3) SNAP implementation requires multidisciplinary support, including integration of respiratory therapists and child life. (4) Individual unit level size, culture and workflow influence implementation (5) Hospital resources and leadership support are important for SNAP implementation.

conclusionsSuccessful SNAP implementation across different contexts will require optimized communication between healthcare team members and the integration of respiratory therapy and child life early in the process of BiPAP initiation. Adapting to the unique features of each institution will be critical.

Indexed as

Acute Chest SyndromeAnemia, Sickle CellNoninvasive VentilationBostonChildFemaleHospitalizationHumansInterviews as TopicMale

Identifiers

PMID40677003
PMCPMC12469202

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.