Evidence map›Paper›PMID 40677018›Full record

GuidelineJournal of pediatric gastroenterology and nutrition2025

Management of paediatric ulcerative colitis, part 1: Ambulatory care-An updated evidence-based consensus guideline from the European Society of Paediatric Gastroenterology, Hepatology and Nutrition and the European Crohn's and Colitis Organisation.

Eytan Wine, Marina Aloi, Stephanie Van Biervliet, Jiri Bronsky, Javier Martín di Carpi, Marco Gasparetto, Laura Gianolio, Hannah Gordon, Iva Hojsak, Alexandra S Hudson and 15 more

Abstract readPractice Guideline
In one paragraph

Guideline in Journal of pediatric gastroenterology and nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 2 syntheses or guidelines pooled it.

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  17. Frontiers in pediatrics · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

25 authors.

Eytan WineDivision of Gastroenterology, Hepatology and Nutrition, The Hospital for Sick Children, Toronto, Ontario, Canada.ORCID https://orcid.org/0000-0002-3458-4142
Marina AloiPediatric Gastroenterology, Hepatology and Cystic Fibrosis Unit, Department of Pathophysiology and Transplantation, University of Milan - Fondazione IRCCS Cà Granda - Ospedale Maggiore Policlinico di Milano, Milan, Italy.ORCID https://orcid.org/0000-0001-7404-4004
Stephanie Van BiervlietPediatric Gastroenterology, Ghent University hospital, Ghent, Belgium.ORCID https://orcid.org/0000-0001-5609-3726
Jiri BronskyDepartment of Paediatrics, University Hospital Motol, Prague, Czech Republic.ORCID https://orcid.org/0000-0002-2641-7280
Javier Martín di CarpiDepartment of Pediatric Gastroenterology, Hepatology and Nutrition, Hospital Sant Joan de Déu, Barcelona, Spain.ORCID https://orcid.org/0000-0002-3631-9625
Marco GasparettoDepartment of Paediatric Gastroenterology, Jenny Lind Children's Hospital, Norfolk and Norwich University Hospitals, Faculty of Medicine and Health Science, University of East Anglia (UEA), Norwich, UK.ORCID https://orcid.org/0000-0002-3882-3606
Laura GianolioDepartment of Paediatrics, Vittore Buzzi Children's Hospital, University of Milan, Milan, Italy.ORCID https://orcid.org/0009-0003-1189-9373
Hannah GordonTranslational Gastroenterology Unit, John Radcliffe Hospital, Oxford University Hospitals NHS Trust, Oxford, UK.ORCID https://orcid.org/0000-0001-7510-0071
Iva HojsakDepartment of Pediatrics, Children's Hospital Zagreb, University of Zagreb Medical School, Referral Center for Pediatric Gastroenterology and Nutrition, Zagreb, Croatia.ORCID https://orcid.org/0000-0003-3262-5964
Alexandra S HudsonDepartment of Pediatrics, Division of Pediatric Gastroenterology, University of Alberta, Edmonton, Alberta, Canada.ORCID https://orcid.org/0000-0001-9016-6917
Séamus HusseyDOCHAS Group, Children's Health Ireland, University College Dublin, Dublin, Ireland.ORCID https://orcid.org/0000-0002-9362-0465
Johan van LimbergenDivision of Paediatric Gastroenterology and Nutrition, Emma Children's Hospital, Amsterdam UMC, Amsterdam, The Netherlands.ORCID https://orcid.org/0000-0001-5822-4371
Erasmo MieleSection of Paediatrics, Department of Translational Medical Science, University of Naples "Federico II", Naples, Italy.ORCID https://orcid.org/0000-0003-4498-7305
Lorenzo NorsaDepartment of Paediatric Gastroenterology, Jenny Lind Children's Hospital, Norfolk and Norwich University Hospitals, Faculty of Medicine and Health Science, University of East Anglia (UEA), Norwich, UK.ORCID https://orcid.org/0000-0003-3322-2921
Ola OlénDepartment of Medicine Solna, Division of Clinical Epidemiology, Karolinska Institutet, Stockholm, Sweden.ORCID https://orcid.org/0000-0002-5478-7019
Gianluca PellinoColorectal Surgery, Vall d'Hebron University Hospital, Universitat Autònoma de Barcelona UAB, Barcelona, Spain.ORCID https://orcid.org/0000-0002-8322-6421
Patrick van RheenenDepartment of Paediatric Gastroenterology Hepatology and Nutrition, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.ORCID https://orcid.org/0000-0003-3867-2665
Lissy de RidderDepartment of Paediatric Gastroenterology, Erasmus MC/Sophia Children's Hospital, Rotterdam, The Netherlands.ORCID https://orcid.org/0000-0002-6035-1182
Richard K RussellDepartment of Paediatric Gastroenterology, Royal Hospital for Children and Young People, Edinburgh, Scotland, UK.ORCID https://orcid.org/0000-0001-7398-4926
Dror S ShouvalSchneider Children's Medical Center of Israel, Institute of Gastroenterology, Nutrition and Liver Diseases, Petah Tikva, Israel.ORCID https://orcid.org/0000-0001-5980-2954
Eunice TrindadePediatric Gastroenterology and Nutrition Unit, Centro Hospitalar Universitário São João, Porto, Portugal.ORCID https://orcid.org/0000-0001-7034-3541
Dan TurnerShaare Zedek Medical Centre, The Juliet Keidan Institute of Paediatric Gastroenterology and Nutrition, Eisenberg R&D Authority, The Hebrew University, Jerusalem, Israel.ORCID https://orcid.org/0000-0001-5160-868X
David C WilsonChild Life and Health, Centre for Inflammation Research, University of Edinburgh, Scotland, UK.ORCID https://orcid.org/0000-0003-0879-1129
Anat Yerushalmy FelerPediatric Gastroenterology Institute, "Dana-Dwek" Children's Hospital, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel.ORCID https://orcid.org/0000-0003-0200-6425
Amit AssaShaare Zedek Medical Centre, The Juliet Keidan Institute of Paediatric Gastroenterology and Nutrition, Eisenberg R&D Authority, The Hebrew University, Jerusalem, Israel.ORCID https://orcid.org/0000-0002-2787-4096

Funding

ESPGHAN
6 · The paper itself

Abstract

objectivesDespite advances in the management of ambulatory paediatric ulcerative colitis (UC), challenges remain as many patients are refractory to therapy and some require colectomy. The aim of these guidelines is to provide an update on optimal care for UC through detailed recommendations and practice points.

methodsThese guidelines are an update to those published in 2018 and are a joint effort of the Paediatric IBD Porto group of European Society of Paediatric Gastroenterology, Hepatology and Nutrition and the European Crohn's and Colitis Organisation. An extensive literature search with subsequent evidence appraisal using the Oxford methodology was performed, followed by three online voting sessions and a consensus face-to-face meeting. Thirty-nine recommendations and 77 practice points were endorsed by the 25 experts with at least an 84% consensus rate.

resultsRobust evidence-based recommendations and detailed practice points are provided. In addition to reemphasising and updating the role of more 'traditional' UC therapies, these guidelines outline optimising the use of antitumour necrosis factor therapies and integrating newer biologics and small molecules, as well as supportive therapy, to improve outcomes and provide an updated management algorithm. Measurement and monitoring tools and decision aids are provided, and additional aspects, including nutritional support, extraintestinal manifestations, pouchitis, inflammatory bowel disease-unclassified and patient support, are discussed. Some aspects, including surgery and thromboprophylaxis, are covered in the acute severe UC guidelines.

conclusionsThese guidelines serve as an aid in managing children with UC through a combination of evidence-based recommendations and more practical practice points in the ambulatory setting.

Indexed as

Ambulatory CareColitis, UlcerativeChildConsensusEuropeEvidence-Based MedicineGastroenterologyHumansSocieties, Medicalbiologicschildreninflammatory bowel disease‐unclassifiedPaediatric Ulcerative Colitis Activity Indexthiopurines

Identifiers

PMID40677018
PMCPMC12408984

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.