Evidence map›Paper›PMID 40677349›Full record

ArticleKidney international reports2025

Kidney Tubular Biomarkers in Type 1 Diabetes - Longitudinal Analysis of 2 Cohorts.

Christine P Limonte, David K Prince, Andrew N Hoofnagle, Irl B Hirsch, Sushrut S Waikar, Alessandro Doria, Michael Mauer, Bryan R Kestenbaum, Ian H de Boer

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Kidney international reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Christine P LimonteDivision of Nephrology, Department of Medicine, University of Washington, Seattle, Washington, USA.
David K PrinceDivision of Nephrology, Department of Medicine, University of Washington, Seattle, Washington, USA.
Andrew N HoofnagleDepartment of Laboratory Medicine and Pathology, Department of Medicine, University of Washington, Seattle, Washington, USA.
Irl B HirschDivision of Metabolism, Endocrinology, and Nutrition, Department of Medicine, University of Washington, Seattle, Washington, USA.
Sushrut S WaikarSection of Nephrology, Boston University School of Medicine and Boston Medical Center, Boston, Massachusetts, USA.
Alessandro DoriaResearch Division, Joslin Diabetes Center, Boston, Massachusetts, USA.
Michael MauerDepartment of Pediatrics and Medicine, University of Minnesota, Minneapolis, Minnesota, USA.
Bryan R KestenbaumDivision of Nephrology, Department of Medicine, University of Washington, Seattle, Washington, USA.
Ian H de BoerDivision of Nephrology, Department of Medicine, University of Washington, Seattle, Washington, USA.

Funding

SPECIAL ASSAY COREP30DK036836 · NIDDK · JOSLIN DIABETES CENTER · PI ROHIT N. KULKARNI · 1986 to 2026
$50.5M
Vector and Transgenic Mouse CoreP30DK017047 · NIDDK · UNIVERSITY OF WASHINGTON · PI Sakeneh Zraika · 1986 to 2026
$41.4M
PILOT STUDY--CLINICAL NUTRITION RESEARCHP30DK035816 · NIDDK · UNIVERSITY OF WASHINGTON · PI GREGORY J MORTON · 1986 to 2026
$30.4M
Pathogenesis of kidney disease in type 1 diabetes: a modern kidney biopsy cohortR01DK132399 · NIDDK · UNIVERSITY OF WASHINGTON · PI Petter Bjornstad, Ian H de Boer · 2022 to 2026
$3.0M
Kidney Tubular Functions in Type 1 DiabetesR01DK125084 · NIDDK · UNIVERSITY OF WASHINGTON · PI DE BOER, IAN H, KESTENBAUM, BRYAN R · 2020 to 2023
$2.7M
Autophagy in Diabetic Kidney DiseaseK23DK135789 · NIDDK · UNIVERSITY OF WASHINGTON · PI Christine Limonte · 2023 to 2026
$753k
NIDDK NIH HHS K23 DK135789NIDDK NIH HHS P30 DK017047NIDDK NIH HHS P30 DK035816NIDDK NIH HHS P30 DK036836NIDDK NIH HHS R01 DK125084NIDDK NIH HHS R01 DK132399
6 · The paper itself

Abstract

Introduction: Kidney tubular biomarker trends may provide insight into tubulointerstitial pathology that is not evident through measurement of glomerular filtration rate (GFR) and albumin excretion rate (AER). Methods: We examined longitudinal changes in tubular biomarkers in 2 type 1 diabetes (T1D) cohorts, namely the Renin-Angiotensin System Study (RASS, Results: At baseline, RASS participants' mean age was 30 years and 47% were male, with mean diabetes duration of 11 years, hemoglobin A1c (HbA1c) of 8.6%, iohexol-based measured GFR (iGFR) of 128 ml/min per 1.73 m Conclusion: Tubular biomarkers significantly worsen over time in T1D, potentially reflecting progression of tubulointerstitial pathology.

Indexed as

diabetic kidney diseasetubular biomarkerstype 1 diabetes

Identifiers

PMID40677349
PMCPMC12266196

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.