ArticleMaterials today. Bio2025
BMSCs-targeting piezoelectric stimulation and immunomodulatory dual-functional hydrogel for promoting diabetic bone regeneration.
Article in Materials today. Bio, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 8 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
8 citing papers in PubMed.
- Electrical Signals at the Subcellular Scale: How Electroactive Materials Regulate Stem Cell Fate.Advanced materials (Deerfield Beach, Fla.) · 2026Review
- A Dual-Bioresponsive and Programmable Microneedle Matrix as a Bioinspired Coupler for Orchestrating Diabetic Bone Regeneration.Advanced materials (Deerfield Beach, Fla.) · 2026Article
- Targeted antibacterial and mesenchymal stem cell-modulatory hydrogel for periodontitis treatment.Materials today. Bio · 2026Article
- 3D-printed triboelectric scaffolds for fabricating BMSC-derived cartilage to repair bone defects and promote endochondral ossification.Bioactive materials · 2026Article
- Exosomal miR-484 from lung adenocarcinoma promotes osteoclastogenesis and osteolytic bone metastasis by targeting PECAM1.Discover oncology · 2026Article
- Biomimetic Nanoparticles for Bone Regeneration: Construction Strategies and Therapeutic Mechanisms.International journal of nanomedicine · 2026Review
- Harnessing piezoelectricity for bone tissue engineering: recapitulating the electrophysiological microenvironment through smart biomaterials.Frontiers in bioengineering and biotechnology · 2026Review
- (Ba,Ca)(Ti,Sn)OFrontiers in cellular neuroscience · 2026Article
Corrections and comments
- Erratum issued
Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bone regeneration in diabetic patients poses a significant clinical challenge due to persistent hyperglycemia and chronic inflammation, which disrupt the crucial interaction between the immune microenvironment and bone marrow-derived mesenchymal stem cells (BMSCs), thereby impairing osteogenesis. To address this limitation, ultrasonic-responsive barium titanate (BTO) nanoparticles were coated with BMSC membranes (B-TNs) and subsequently integrated into a carboxylated modified silk fibroin (CMS) hydrogel. This resulted in a dual-functional B-TNs@CMS composite hydrogel designed to combine targeted BMSC stimulation with immunomodulatory properties. Under diabetic conditions, the composite hydrogel facilitated macrophage polarization from the pro-inflammatory M1 phenotype to the anti-inflammatory M2 phenotype. Proteomic analysis and validation assays demonstrated that CMS reprograms macrophages through the PI3K-Akt-mTORC1 signaling axis, thereby restoring an osteogenesis-supportive immune microenvironment conducive to osteogenesis. Simultaneously, the degradation of CMS released B-TNs, which produced a moderate level of reactive oxygen species (ROS) under optimized extracorporeal ultrasound (US) stimulation. This process activated Wnt/β-catenin signaling, enhancing BMSC proliferation and osteogenic differentiation. This study highlights the significant potential of a dual-modular strategy integrating immune modulation with spatially targeted osteogenic stimulation, offering a promising therapeutic approach for diabetic bone regeneration.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.