Evidence map›Paper›PMID 40677502›Full record

ArticleCureus2025

From Cholesterol Control to Critical Illness: A Case of Statin-Associated Rhabdomyolysis With Concurrent Acute Kidney Injury and Hepatotoxicity.

Bola Habeb, Sandy Khair, Seth Fowler

Abstract readCase Reports
In one paragraph

Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Bola HabebInternal Medicine, University of Florida College of Medicine, Ascension Sacred Heart, Pensacola, USA.
Sandy KhairRadiation Oncology, Cairo University, National Cancer Institute, Cairo, EGY.
Seth FowlerInternal Medicine, University of Florida College of Medicine, Ascension Sacred Heart, Pensacola, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Statins, or HMG-CoA reductase inhibitors, are among the most commonly prescribed medications globally due to their well-established efficacy in lowering low-density lipoprotein cholesterol (LDL-C) and reducing the risk of atherosclerotic cardiovascular disease. Their widespread use in both primary and secondary prevention strategies has significantly contributed to declines in cardiovascular morbidity and mortality. Despite their favorable safety profile, statins are not without risk. Rare but potentially life-threatening complications such as rhabdomyolysis, hepatotoxicity, and acute kidney injury (AKI) can occur, particularly in individuals with specific risk factors, such as advanced age, renal impairment, high-dose therapy, or concurrent use of drugs that alter statin metabolism. Understanding the spectrum and mechanisms of these adverse effects is essential for prompt identification and management to prevent serious outcomes.

Indexed as

drug-induced toxicitynon-traumatic rhabdomyolysisrhabdomyolysis causing acute kidney injuryside effects of statinsstatin-induced hepatitisstatin-induced rhabdomyolysis

Identifiers

PMID40677502
PMCPMC12269334

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.