ReviewFrontiers in immunology2025
Bacterial interactions with platelets: defining key themes.
Review in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Inflammation, anemia, and vitamin D levels associate with infant thrombocytosis risk.Research and practice in thrombosis and haemostasis · 2026Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
As first responders to vascular injury and microbial invasion, platelets play a critical role in hemostasis and immunity. Previous reviews have explored how different platelet receptors can be activated by various bacterial proteins, yet strain-specific perspectives remain underexplored. In this review, we highlight eight bacterial strains that have been associated with thrombosis, each possessing unique proteins or toxins capable of activating or modulating platelets. We discuss some common themes in the molecular interactions between these bacterial components and their effects on platelet function. Some interactions influence platelet aggregation, granule secretion, pro-inflammatory cytokine release, and thrombo-inflammatory responses, while others only mediate bacterial survival. By focusing on strain-specific mechanisms, this review provides an understanding of the different strategies employed by bacteria to manipulate platelet functions. These insights may aid in developing targeted therapeutic interventions to mitigate platelet-associated complications during bacterial infections.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.