Evidence map›Paper›PMID 40678024›Full record

ArticleReceptors (Basel, Switzerland)2025

Evaluation of [

Allyson Ngo, Fariha Karim, Oshini V Keerthisinghe, Tram B Danh, Christopher Liang, Jogeshwar Mukherjee

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Receptors (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Increased Binding of [Synapse (New York, N.Y.) · 2026
    Article
  2. Assessment of [Biomolecules · 2025
    Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Allyson NgoPreclinical Imaging, Department of Radiological Sciences, University of California-Irvine, Irvine, CA 92697, USA.ORCID 0009-0002-6993-9131
Fariha KarimPreclinical Imaging, Department of Radiological Sciences, University of California-Irvine, Irvine, CA 92697, USA.ORCID 0009-0001-3104-9523
Oshini V KeerthisinghePreclinical Imaging, Department of Radiological Sciences, University of California-Irvine, Irvine, CA 92697, USA.
Tram B DanhPreclinical Imaging, Department of Radiological Sciences, University of California-Irvine, Irvine, CA 92697, USA.
Christopher LiangPreclinical Imaging, Department of Radiological Sciences, University of California-Irvine, Irvine, CA 92697, USA.ORCID 0000-0001-9081-294X
Jogeshwar MukherjeePreclinical Imaging, Department of Radiological Sciences, University of California-Irvine, Irvine, CA 92697, USA.ORCID 0000-0003-1009-877X

Funding

CORE--NEUROPATHOLOGYP30AG019610 · SUN HEALTH RESEARCH INSTITUTE · 2001 to 2005
$4.7M
Novel Tau-Targeted Radiohalogenated Agents for Alzheimer's DiseaseR01AG077700 · UNIVERSITY OF CALIFORNIA-IRVINE · 2025 to 2025
$698k
NIA NIH HHS P30 AG019610NIA NIH HHS R01 AG029479NIA NIH HHS R01 AG077700NIA NIH HHS R21 AG079189NIA NIH HHS RF1 AG029479NINDS NIH HHS U24 NS072026
6 · The paper itself

Abstract

Background/Objectives: Alzheimer's disease (AD) severely hinders cognitive function in the hippocampus (HP) and subiculum (SUB), impacting the expression of nicotinic acetylcholine receptors (nAChRs) such as the α7-subtype. To investigate α7 nAChRs as a potential PET imaging biomarker, we report the quantitative binding of [ Methods: For comparisons with common AD biomarkers, adjacent slices were anti-Aβ and anti-Tau immunostained for analysis using QuPath. Results: The [ Conclusions: [

Indexed as

[125I]α-BungarotoxinAlzheimer’s diseasehippocampushuman Aβ plaqueshuman tau tanglesPET imagingα7 nicotinic acetylcholine receptors

Identifiers

PMID40678024
PMCPMC12269802

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.