Evidence map›Paper›PMID 40679333›Full record

ArticleInvestigative ophthalmology & visual science2025

En Face OCT and the Phenotype Characterization of Drusen.

Shilo Voichanski, Elodie Bousquet, Neda Abraham, Mostafa Mafi, Ahmad Santina, Claudia Fossataro, Federica Fossataro, Ye He, SriniVas Sadda, David Sarraf

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Investigative ophthalmology & visual science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Non neovascular Age - related macular degeneration - Review on clinical and imaging advances.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2026
    Review
  3. Review
  4. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Shilo VoichanskiRetinal Disorders and Ophthalmic Genetics Division, Jules Stein Eye Institute, David Geffen School of Medicine-UCLA, University of California, Los Angeles, Los Angeles, California, United States.
Elodie BousquetRetinal Disorders and Ophthalmic Genetics Division, Jules Stein Eye Institute, David Geffen School of Medicine-UCLA, University of California, Los Angeles, Los Angeles, California, United States.
Neda AbrahamRetinal Disorders and Ophthalmic Genetics Division, Jules Stein Eye Institute, David Geffen School of Medicine-UCLA, University of California, Los Angeles, Los Angeles, California, United States.
Mostafa MafiRetinal Disorders and Ophthalmic Genetics Division, Jules Stein Eye Institute, David Geffen School of Medicine-UCLA, University of California, Los Angeles, Los Angeles, California, United States.
Ahmad SantinaRetinal Disorders and Ophthalmic Genetics Division, Jules Stein Eye Institute, David Geffen School of Medicine-UCLA, University of California, Los Angeles, Los Angeles, California, United States.
Claudia FossataroRetinal Disorders and Ophthalmic Genetics Division, Jules Stein Eye Institute, David Geffen School of Medicine-UCLA, University of California, Los Angeles, Los Angeles, California, United States.
Federica FossataroRetinal Disorders and Ophthalmic Genetics Division, Jules Stein Eye Institute, David Geffen School of Medicine-UCLA, University of California, Los Angeles, Los Angeles, California, United States.
Ye HeRetinal Disorders and Ophthalmic Genetics Division, Jules Stein Eye Institute, David Geffen School of Medicine-UCLA, University of California, Los Angeles, Los Angeles, California, United States.
SriniVas SaddaDoheny Eye Institute, Department of Ophthalmology, University of California, Los Angeles, Los Angeles, California, United States.
David SarrafRetinal Disorders and Ophthalmic Genetics Division, Jules Stein Eye Institute, David Geffen School of Medicine-UCLA, University of California, Los Angeles, Los Angeles, California, United States.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Purpose: To detect and differentiate the various subtypes of drusen and subretinal drusenoid deposits (SDDs) using single-capture en face spectral-domain optical coherence tomography (SD-OCT) imaging. Methods: This study was a retrospective case series. Sixty-six eyes of 37 patients with evidence of soft, cuticular, and calcified drusen and SDDs were analyzed. Structural en face OCT images were reconstructed using two 40-µm-thick slabs and one 400-µm-thick slab positioned at different levels above and below Bruch's membrane. The various features captured with en face OCT at different levels of segmentation were applied to study and classify the subtypes of drusen and SDDs. Results: Dot and ribbon SDDs were clearly captured with outer retina slab segmentation. Soft, cuticular, and calcified drusen were captured with the retinal pigment epithelium (RPE) slab, and all demonstrated a version of the donut sign. The choroidal slab showed reverse donuts representing cuticular drusen, dark lesions due to severe shadowing from calcified drusen, and a slightly attenuated signal representing soft drusen. Conclusions: En face OCT is a simple and practical tool to phenotype the various classes of drusen and SDDs. Composition differences between the various drusen and SDDs can be captured with en face OCT at varying segmentation levels due to differences in light reflectance and penetration characteristics. These OCT features provide a more in-depth understanding of the various subtypes of drusen and SDDs and can enhance phenotype characterization, which can improve clinical care, clinical trial recruitment, and reading center performance.

Indexed as

Retinal DrusenRetinal Pigment EpitheliumTomography, Optical CoherenceAdultAgedAged, 80 and overBruch MembraneFemaleFluorescein AngiographyHumansMaleMiddle AgedPhenotypeRetrospective Studies

Identifiers

PMID40679333
PMCPMC12302042

What Socratic holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.