Trial reportThe Journal of clinical endocrinology and metabolism2026
Myofibrillar Protein Synthesis Rates Do not Differ With Low and High Estradiol Concentrations Across the Menstrual Cycle.
Trial report in The Journal of clinical endocrinology and metabolism, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Age-related anabolic resistance and post-absorptive muscle protein synthesis: integrative evidence from a systematic review and meta-analysis.Frontiers in physiology · 2026Pooled it
- Myofibrillar Protein Synthesis Rates Do not Differ With Low and High Estradiol Concentrations Across the Menstrual Cycle.The Journal of clinical endocrinology and metabolism · 2026Trial
- An Overview of the Impact of the Menstrual Cycle on Nutrient Metabolism: An Integrative Perspective.Nutrients · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
Abstract
contextSkeletal muscle can respond and adapt to sex hormones; however, the degree to which fluctuations in endogenous estradiol across the menstrual cycle (MC) influences rates of myofibrillar protein synthesis (MyoPS) is not clear.
objectiveWe compared MyoPS in postabsorptive and postprandial postexercise states, during the early follicular (EF; low estradiol) and late follicular (LF; high estradiol) phases of the MC.
methodsSeventeen healthy women (age: 28 ± 7 y; body mass index: 24 ± 3 kg.m2), participated in a randomized, crossover trial, during the EF (day 4 ± 1; estradiol, 183 ± 78 pmol.L-1) and LF (day 15 ± 3; estradiol, 855 ± 571 pmol.L-1) phases. Following a resistance exercise bout, participants ingested an amino acid (AA) drink. Blood and muscle samples were collected, pre and post exercise and AA ingestion. Following primed-continuous infusion of L-[ring-2H5]-phenylalanine, MyoPS was measured prior to and during a 4 hour postprandial postexercise period.
resultsMyoPS increased above postabsorptive rates between 0-2 hours to 0.111 ± 0.049 and 0.117 ± 0.058%.h-1 (P < .001) but not between 2-4 hours (P = .522), for EF and LF, respectively, with no interactions observed (P = .971). Moderate correlations were shown between total and free testosterone and 0-4 hour MyoPS (r = 0.364, P = .048; r = 0.369, P = .045, respectively). Expression of several genes associated with protein synthesis, muscle remodeling, and inflammation were increased in LF vs EF (P < .050), whereas protein breakdown genes were decreased.
conclusionDespite a gene expression profile consistent with muscle growth, MyoPS did not differ with elevated estradiol concentrations. Hence, estradiol does not seem to be important for acutely regulating muscle mass in eumenorrheic women.
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