Evidence map›Paper›PMID 40679672›Full record

ReviewDiscover oncology2025

Non-coding RNAs and Hippo signaling in non-small cell lung cancer: emerging roles as biomarkers and therapeutic targets.

Mohammadamin Joulani, Nahal Aghajamal, Masoumeh Nouri, Faraz Rahmani Khajeh, Nafiseh Sharifi, Dena Saghafi, Mahan Amiri, Ali Abdollahzadeh, Ehsan Heidari, Amin Mirdamadian and 5 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Discover oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Mohammadamin Joulani *Student Research Committee, Faculty of Medicine, Iran University of Medical Sciences, Tehran, 009821, Iran.
Nahal Aghajamal *Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, 00984, Iran.
Masoumeh NouriSurgical Oncology Research Centre, Mashhad University of Medical Science, Mashhad, 009851, Iran.
Faraz Rahmani KhajehStudent Research Committee of Tabriz University of Medical Sciences, Tabriz, 00984, Iran.
Nafiseh SharifiDepartment of Biology, Faculty of Molecular and Cell Biology, Falavarjan Branch, Islamic Azad University, Esfahan, 009829, Iran.
Dena SaghafiTehran Medical Sciences Branch, Islamic Azad University, Tehran, 009821, Iran.
Mahan AmiriDepartment of Molecular Genetics, Faculty of Biological Sciences, Tarbiat Modares University, Tehran, 009821, Iran.
Ali AbdollahzadehSchool of Medicine, Tabriz Azad University of Medical Sciences, Tabriz, 00984, Iran.
Ehsan HeidariDepartment of Pharmacy, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, 009821, Iran.
Amin MirdamadianFaculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, 009821, Iran.
Malihe SharafiDepartment of Biology, Faculty of Basic Sciences, Azarbaijan Shahid Madani University, Tabriz, 00984, Iran.
Samira MasoumiIslamic Azad University, Pharmaceutical Sciences Branch, Tehran, 009821, Iran.
Reza MorovatshoarMolecular Medicine Research Center, Hormozgan Health Institute, Hormozgan University of Medical Sciences, Bandar Abbas, 009876, Iran.
Alireza AzaniTehran Medical Sciences Branch, Islamic Azad University, Tehran, 009821, Iran. Azanyalireza30@gmail.com.
Qumars BehfarNational Institute for Health Research, Tehran University of Medical Sciences, Tehran, 009821, Iran. q_behfar@yahoo.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The most common type of cancer and one with a high death rate is lung cancer, especially non-small cell lung cancer (NSCLC), which is mostly brought on by medication resistance, metastasis, and delayed diagnosis. The discovery of non-coding RNAs (ncRNAs), such as circular RNAs (circRNAs), long non-coding RNAs (lncRNAs), and microRNAs (miRNAs), has revealed their vital involvement in the pathophysiology of lung cancer by controlling important cellular processes. The Hippo signaling pathway is one of the critical routes impacted by non-coding RNAs. It is involved in tumor suppression, apoptosis, and cell proliferation. The interaction between ncRNAs and the Hippo pathway in lung cancer is reviewed in this review, with an emphasis on the potential of these molecules as therapeutic targets as well as diagnostic and prognostic biomarkers.

Indexed as

Circular RNAsHippo signaling pathwayLong non-coding RNAsLung cancerMicroRNAsNon-coding RNAs

Identifiers

PMID40679672
PMCPMC12274179

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.