Evidence map›Paper›PMID 40680136›Full record

ArticleScience advances2025

Role of d-serine in intestinal ROS accumulation after sleep deprivation.

Feng Zheng, Shuai Liu, Tian Wei, Lei Wang, Yuanyuan Chang, Hao Qu, Lei Zheng

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Science advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Metabolites · 2026
    Article
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Feng ZhengSchool of Food and Biological Engineering, Hefei University of Technology, Hefei, China.ORCID 0009-0008-6392-7029
Shuai LiuSchool of Food and Biological Engineering, Hefei University of Technology, Hefei, China.ORCID 0000-0001-8319-6376
Tian WeiDepartment of Toxicology, School of Public Health, Anhui Medical University, Hefei, China.ORCID 0000-0001-7270-0979
Lei WangSchool of Food and Biological Engineering, Hefei University of Technology, Hefei, China.ORCID 0009-0003-3443-5678
Yuanyuan ChangSchool of Food and Biological Engineering, Hefei University of Technology, Hefei, China.ORCID 0009-0008-0167-8215
Hao QuSchool of Food and Biological Engineering, Hefei University of Technology, Hefei, China.ORCID 0000-0002-5834-8080
Lei ZhengSchool of Food and Biological Engineering, Hefei University of Technology, Hefei, China.ORCID 0000-0001-6222-2344

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Prolonged sleep deprivation (SD) results in increased accumulation of reactive oxygen species (ROS) in gut, although the underlying mechanisms remain to be elucidated. This study identifies d-serine as a crucial regulator of gut ROS during SD. Knockdown of serine racemase (SR), the enzyme responsible for d-serine production, prevents the enhanced ROS buildup during SD in

Indexed as

Intestinal MucosaReactive Oxygen SpeciesSerineSleep DeprivationAnimalsEnterocytesIntestinesLipid MetabolismMitochondriaRacemases and EpimerasesReceptors, N-Methyl-D-AspartateSerine RacemaseSignal TransductionRacemases and EpimerasesReactive Oxygen SpeciesReceptors, N-Methyl-D-AspartateSerineSerine Racemase

Identifiers

PMID40680136
PMCPMC12273795

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.