Evidence map›Paper›PMID 40682186›Full record

ArticleDiabetology & metabolic syndrome2025

Weight loss mediates improvement in proinsulin processing during GLP-1 receptor agonist treatment.

Renjiao Liu, Dangmin Hou, Mingxin Leng, Zhouhuiling Li, Yifang Zhang, Lingling Liu, Xincheng Wang, Chunjun Li

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Diabetology & metabolic syndrome, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Renjiao LiuHealth Management Center, Tianjin Union Medical Center, The First Affiliated Hospital of Nankai University, No. 190 of Jieyuan Road, Hongqiao District, Tianjin, 300121, China.
Dangmin HouTianjin University of Traditional Chinese Medicine, Tianjin, China.
Mingxin LengGraduate School, Tianjin Medical University, Tianjin, China.
Zhouhuiling LiTianjin University of Traditional Chinese Medicine, Tianjin, China.
Yifang ZhangNankai University, Tianjin, China.
Lingling LiuTianjin University of Traditional Chinese Medicine, Tianjin, China.
Xincheng WangHealth Management Center, Tianjin Union Medical Center, The First Affiliated Hospital of Nankai University, No. 190 of Jieyuan Road, Hongqiao District, Tianjin, 300121, China.
Chunjun LiHealth Management Center, Tianjin Union Medical Center, The First Affiliated Hospital of Nankai University, No. 190 of Jieyuan Road, Hongqiao District, Tianjin, 300121, China. li_chunjun@126.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimsTo observe the effect of glucagon-like peptide-1 receptor agonists (GLP-1RA) combined with metformin and metformin monotherapy on proinsulin changes in patients with obesity following weight loss. To explore whether the changes of proinsulin were related to GLP-1RA or secondary to weight reduction.

methods100 adults with obesity (BMI ≥ 28 kg/m

resultsThe weight, blood lipids and glucose metabolism indexes of two groups were significantly improved, and the effects were more significant in the GLP-1RA group. Correlation analysis showed that proinsulin change was positively correlated with body weight change and VFA change, which persisted after adjusting for confounding factors such as age, gender, baseline body mass index (BMI), and GLP-1RA medication.

conclusionGLP-1RA demonstrate superior weight loss effects and improvements in lipid and glucose metabolism in patients with obesity. However, the reduction in proinsulin levels is primarily attributed to the magnitude of weight loss itself, independent of GLP-1RA use.

Indexed as

GLP-1RAsObesityProinsulinWeight loss

Identifiers

PMID40682186
PMCPMC12275330

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.