ReviewDiabetology & metabolic syndrome2025
Effect of vitamin D supplementation on body composition, lipid profile, and glycemic indices in patients with obesity-associated metabolic syndrome: a systematic review and meta-analysis.
Review in Diabetology & metabolic syndrome, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
9 citing papers in PubMed.
- VDR BsmI polymorphism and obesity in vitamin D deficiency among undergraduate students: a cross-sectional study.Molecular biology reports · 2026Article
- Effects of orange juice enriched with probiotics and vitamin D3 on glucose metabolism in high-cardiometabolic risk individuals: secondary outcomes of a randomised controlled trial.European journal of clinical nutrition · 2026Article
- Article
- Probiotic-Mediated Vitamin D Supplementation Improves the Gut Microbiota and Vitamin D Receptor Composition in Obese Rats.Food science & nutrition · 2026Article
- Vitamin D in Cardiovascular Medicine: From Molecular Mechanisms to Clinical Translation.Nutrients · 2026Review
- Vitamin D Supplementation for Steatotic Liver Disease: an Updated Systematic Review and Dose-Response Meta-analysis of Randomized and Nonrandomized Interventional Studies.Current developments in nutrition · 2026Review
- Serum 25-hydroxyvitamin D and metabolic syndrome: a large cross-section study with dose response analysis in a health screening population.Frontiers in nutrition · 2026Article
- Associations of vitamin D, hepatic function and inflammatory biomarkers with obesity: A cross-sectional analysis.Bioinformation · 2026Article
- The Impact of Overweight Among Children on Salivary Vitamin D, Calcium, and Magnesium in Relation to Dental Caries Severity.International journal of dentistry · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundVitamin D deficiency is common among individuals with obesity and metabolic disorders. Evidence on its effect on metabolic markers remains inconclusive. This systematic review and meta-analysis aimed to evaluate the impact of vitamin D supplementation on lipid profile, glycemic control, and anthropometric indices.
methodsA comprehensive search of PubMed, Embase, Cochrane Library, Web of Science, and China Knowledge Network was conducted from inception to May 2024. Randomized controlled trials (RCTs) evaluating oral vitamin D supplementation in adults with overweight, obesity, or metabolic disorders were included. Weighted mean differences (WMDs) and 95% confidence intervals (CIs) were calculated using a random-effects model.
resultsTwenty-five RCTs (30 arms) were included. Overall, vitamin D supplementation did not significantly affect triglycerides (TG), total cholesterol (TC), HDL-C, LDL-C, fasting plasma glucose (FPG), insulin, HOMA-IR, HbA1c, waist circumference (WC), or body weight (p < 0.05). Subgroup analyses showed significant effects in certain populations, such as increased HDL-C in individuals with diabetes and elevated LDL-C in younger adults and males. A significant reduction in BMI was observed after adjusting for publication bias (p < 0.05). Heterogeneity varied across outcomes, and risk of bias was generally low, although some studies had unclear reporting.
conclusionVitamin D supplementation has limited effects on metabolic and anthropometric markers in adults with obesity or related metabolic disorders. Certain subgroups may benefit, warranting further targeted research.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.