Evidence map›Paper›PMID 40682691›Full record

ReviewBiogerontology2025

Aging influences protein digestion, absorption and amino acid metabolism.

Lili Qiu, Qianqian Huang, Wenhao Li, Qian Zhang, Jun Zhou, Juan Chen, Yixuan Li, Ran Wang, Pengjie Wang, Siyuan Liu and 2 more

Abstract readReview
PubMed Publisher
In one paragraph

Review in Biogerontology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Review
  7. Nutrients · 2026
    Article
  8. Review
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Lili QiuKey Laboratory of Precision Nutrition and Food Quality, Department of Nutrition and Health, China Agricultural University, Beijing, 100193, China.
Qianqian HuangCollege of Food Science and Nutritional Engineering, China Agricultural University, Beijing, 100083, China.
Wenhao LiKey Laboratory of Precision Nutrition and Food Quality, Department of Nutrition and Health, China Agricultural University, Beijing, 100193, China.
Qian ZhangKey Laboratory of Precision Nutrition and Food Quality, Department of Nutrition and Health, China Agricultural University, Beijing, 100193, China.
Jun ZhouCollege of Food Science and Nutritional Engineering, China Agricultural University, Beijing, 100083, China.
Juan ChenKey Laboratory of Precision Nutrition and Food Quality, Department of Nutrition and Health, China Agricultural University, Beijing, 100193, China.
Yixuan LiKey Laboratory of Precision Nutrition and Food Quality, Department of Nutrition and Health, China Agricultural University, Beijing, 100193, China.
Ran WangKey Laboratory of Precision Nutrition and Food Quality, Department of Nutrition and Health, China Agricultural University, Beijing, 100193, China.
Pengjie WangKey Laboratory of Precision Nutrition and Food Quality, Department of Nutrition and Health, China Agricultural University, Beijing, 100193, China.
Siyuan LiuKey Laboratory of Precision Nutrition and Food Quality, Department of Nutrition and Health, China Agricultural University, Beijing, 100193, China.
Bing FangKey Laboratory of Precision Nutrition and Food Quality, Department of Nutrition and Health, China Agricultural University, Beijing, 100193, China. bingfang@cau.edu.cn.
Xiaoyu WangKey Laboratory of Precision Nutrition and Food Quality, Department of Nutrition and Health, China Agricultural University, Beijing, 100193, China. xy.wang@cau.edu.cn.

Funding

the National Key R&D Program of China Grant No.2023YFF1104502the Young Elite Scientists Sponsorship Program by CAST NO.2022QNRC001
6 · The paper itself

Abstract

Proteins are essential biomolecules that play indispensable roles in maintaining cellular homeostasis and regulating systemic metabolic processes. Protein deficiency is closely associated with age-related chronic diseases. Our purpose is to reveal the reason of protein deficiency in the elderly and potential treatments. A systematic literature search mainly on human studies addressing gastrointestinal aging and amino acid homeostasis was conducted. This review investigated the effects of aging on protein metabolism and summarized age-related physiological changes that collectively disrupt protein homeostasis. These changes include reduced secretion of gastric acid and digestive enzymes, which impair protein digestion in the stomach and small intestine. Weakened intestinal motility further delays the transit of digested proteins, reducing the efficiency of amino acid absorption. Additionally, decreased function of amino acid transporter proteins in the intestines and muscles limits the availability of amino acids for protein synthesis. Impaired liver and kidney function exacerbates these issues by affecting amino acid catabolism and clearance. Together, these alterations lead to an imbalance in amino acid homeostasis, contributing to protein deficiency, increasing the risk of sarcopenia in the elderly. Overall, we highlight changes in protein digestion, absorption, and amino acid metabolism in the elderly, and gives the possibility of improving amino acid utilization efficiency in the elderly, paving the way for new treatments for age-related protein deficiency in the future.

Indexed as

AgingAmino AcidsDigestionIntestinal AbsorptionProteinsAnimalsHomeostasisHumansProtein DeficiencySarcopeniaAmino AcidsProteinsAmino acid metabolismDigestion and absorptionElderlyGastrointestinal tractProtein

Identifiers

PMID40682691

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.