Evidence map›Paper›PMID 40682841›Full record

ArticleOncology reports2025

High expression of eIF4A1 promotes angiogenesis through the NF‑κB/VEGFA pathway and predicts poor prognosis in gastric cancer.

Xiaoqun Zhu, Lizhou Jia, Xingwang Kuai, Qi Tang, Xinxia Chang, Xiao Zhang, Bing Chen, Hui Zhi, Haoran Hu, Xiaomei Huang and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Oncology reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Xiaoqun ZhuDepartment of Pathology, Wannan Medical College, Wuhu, Anhui 241002, P.R. China.
Lizhou JiaNational Health Commission Key Laboratory of Antibody Techniques, Nanjing Medical University, Nanjing, Jiangsu 210000, P.R. China.
Xingwang KuaiDepartment of Pathology, Medical School of Nantong University, Nantong, Jiangsu 226000, P.R. China.
Qi TangNational Health Commission Key Laboratory of Antibody Techniques, Nanjing Medical University, Nanjing, Jiangsu 210000, P.R. China.
Xinxia ChangNational Health Commission Key Laboratory of Antibody Techniques, Nanjing Medical University, Nanjing, Jiangsu 210000, P.R. China.
Xiao ZhangNational Health Commission Key Laboratory of Antibody Techniques, Nanjing Medical University, Nanjing, Jiangsu 210000, P.R. China.
Bing ChenDepartment of Pathology, Wannan Medical College, Wuhu, Anhui 241002, P.R. China.
Hui ZhiDepartment of Pathology, Wannan Medical College, Wuhu, Anhui 241002, P.R. China.
Haoran HuDepartment of Pathology, Wannan Medical College, Wuhu, Anhui 241002, P.R. China.
Xiaomei HuangDepartment of Pathology, Wannan Medical College, Wuhu, Anhui 241002, P.R. China.
Zhenqing FengNational Health Commission Key Laboratory of Antibody Techniques, Nanjing Medical University, Nanjing, Jiangsu 210000, P.R. China.
Wenbin HuangDepartment of Pathology, The First Affiliated Hospital of Henan University of Science and Technology, Luoyang, Henan 471000, P.R. China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Increased eukaryotic translation initiation factor 4A (eIF4A1) expression is observed in numerous types of cancer and is associated with carcinogenesis; however, little is known about the role of eIF4A1 in gastric cancer (GC) angiogenesis. In the present study, a total of 1,758 gastric mucosa samples were collected for immunohistochemical staining in tissue microarrays. The expression levels of eIF4A1 and their association with clinicopathological characteristics and prognosis were analyzed using χ

Indexed as

Biomarkers, TumorEukaryotic Initiation Factor-4ANeovascularization, PathologicNF-kappa BStomach NeoplasmsVascular Endothelial Growth Factor AAdultAgedAngiogenesisAnimalsCell Line, TumorCell MovementCell ProliferationFemaleGene Expression Regulation, NeoplasticHumansBiomarkers, TumorEukaryotic Initiation Factor-4ANF-kappa BVascular Endothelial Growth Factor AVEGFA protein, humanangiogenesiseukaryotic translation initiation factor 4Agastric cancerNF‑κBprognosisVEGFA

Identifiers

PMID40682841
PMCPMC12308842

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.