ReviewNeuron2025
Accelerating biomedical discoveries in brain health through transformative neuropathology of aging and neurodegeneration.
Abstract readReview
In one paragraph
Review in Neuron, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
10 citing papers in PubMed.
- The applications of single-cell and spatial transcriptomics in neuroscience and brain disorders.Neuroscience and biobehavioral reviews · 2026Review
- Article
- Digital Atlases to Unlock the Potential of Brain Biorepository Tissues for Interdisciplinary Research.bioRxiv : the preprint server for biology · 2026Article
- Four decades of Alzheimer's disease discoveries, data, and research resources: The NIH Alzheimer's Disease Research Center Program.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Modeling small vessel disease burden and vascular dementia likelihood from NACC data.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Digital neuropathology of neurodegenerative disorders: Foundations, research advances, and future directions.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Review
- Unraveling the Effects ofInternational journal of molecular sciences · 2025Review
- Celebrating neuropathology's contributions to Alzheimer's Disease Research Centers.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- The Neurofibrillary Tangle Maturity Scale: A Novel Framework for Tangle Pathology Evaluation in Alzheimer's Disease.bioRxiv : the preprint server for biology · 2025Article
- Mapping neurodegeneration with diffusion MRI: biomarkers, mechanisms, and clinical translation.Frontiers in neurologyReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
46 authors.
Melissa E MurrayDepartment of Neuroscience, Mayo Clinic Jacksonville, Jacksonville, FL, USA; Department of Laboratory Medicine and Pathology, Mayo Clinic Jacksonville, Jacksonville, FL, USA. Electronic address: murray.melissa@mayo.edu.
Colin SmithCentre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK.
Vilas MenonDepartment of Neurology, Columbia University, New York, NY, USA; Center for Translational and Computational Neuroimmunology, Department of Neurology, Columbia University Irving Medical Center, New York, NY, USA.
C Dirk KeeneDepartment of Laboratory Medicine and Pathology, University of Washington School of Medicine, Seattle, WA, USA; Department of Laboratory Medicine and Pathology, University of Washington School of Medicine, Seattle, WA, USA.
Ed LeinAllen Institute for Brain Science, Seattle, WA, USA; Department of Laboratory Medicine and Pathology, University of Washington, Seattle, WA, USA.
Michael HawrylyczAllen Institute for Brain Science, Seattle, WA, USA.
Adriano AguzziInstitute of Neuropathology, University of Zurich, Zurich, Switzerland.
Brett BenedettiChan Zuckerberg Initiative (CZI), Redwood City, CA, USA.
Katja BroseChan Zuckerberg Initiative (CZI), Redwood City, CA, USA.
Kelsey Caetano-AnollesDepartment of Neuroscience, Mayo Clinic Jacksonville, Jacksonville, FL, USA.
Maria Inmaculada Cobos SilleroDepartment of Pathology, Stanford University School of Medicine, Stanford, CA, USA.
John F CraryDepartment of Pathology, Nash Family Department of Neuroscience, Department of Artificial Intelligence & Human Health, Neuropathology Brain Bank & Research CoRE, Ronald M. Loeb Center for Alzheimer's Disease, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Philip L De JagerCenter for Translational and Computational Neuroimmunology, Department of Neurology, Columbia University Irving Medical Center, New York, NY, USA; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Irving Medical Center, New York, NY, USA.
Arline FaustinDepartment of Pathology, NYU Langone Health and NYU Grossman School of Medicine, New York, NY, USA.
Margaret E FlanaganGlenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases, University of Texas Health, San Antonio, San Antonio, TX, USA; Department of Pathology, University of Texas Health, San Antonio, San Antonio, TX, USA.
Ozgun GokceDepartment of Old Age Psychiatry and Cognitive Disorders, University Hospital Bonn, Bonn, Germany; German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.
Seth G N GrantCentre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK.
Lea T GrinbergMemory and Aging Center, University of California, San Francisco, San Francisco, CA, USA.
David A GutmanEmory University School of Medicine, Atlanta, GA, USA.
Elizabeth M C HillmanZuckerman Mind Brain Behavior Institute and Departments of Biomedical Engineering and Radiology, Columbia University, New York, NY, USA.
Zhi HuangPerelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
David J IrwinPerelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
David T JonesDepartment of Neurology, Mayo Clinic, Rochester, MN, USA; Department of Radiology, Mayo Clinic, Rochester, MN, USA.
Alifiya KapasiRush University Medical Center, Rush Alzheimer's Disease Center, Chicago, IL, USA.
Celeste M KarchDepartment of Psychiatry, Knight Alzheimer Disease Research Center, Washington University in St. Louis, St. Louis, MO, USA.
Walter T KukullDepartment of Laboratory Medicine and Pathology, University of Washington School of Medicine, Seattle, WA, USA.
Tammaryn LashleyDepartment of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, London, UK.
Edward B LeePerelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Thomas LehnerNew York Genome Center, New York, NY, USA.
Laura ParkkinenNuffield Department of Clinical Neurosciences, Oxford Parkinson's Disease Center, University of Oxford, Oxford, UK.
Maria PedersenNew York Genome Center, New York, NY, USA.
Dominique PritchettDepartment of Biology, Howard University, Washington, DC, USA.
Matthew H RutledgeQuantitative Health Sciences, Mayo Clinic Jacksonville, Jacksonville, FL, USA.
Julie A SchneiderRush University Medical Center, Rush Alzheimer's Disease Center, Chicago, IL, USA.
William W SeeleyMemory and Aging Center, University of California, San Francisco, San Francisco, CA, USA.
Claire E ShepherdDepartment of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, London, UK; School of Biomedical Sciences, University of New South Wales, Sydney, NSW, Australia.
Tara L Spires-JonesCentre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK.
Judith A SteenDepartment of Neurology, Harvard Medical School, Boston, MA, USA; Neuroproteomics Laboratory, Kirby Center, Boston Children's Hospital, Boston, MA, USA.
Margaret SutherlandChan Zuckerberg Initiative (CZI), Redwood City, CA, USA.
Sanja VickovicNew York Genome Center, New York, NY, USA; Department of Biomedical Engineering and Herbert Irving Institute for Cancer Dynamics, Columbia University, New York, NY, USA.
Bin ZhangDepartment of Genetics & Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
David J StewartCold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA.
Michael J KeiserInstitute for Neurodegenerative Diseases, University of California, San Francisco, San Francisco, CA, USA.
Jacob W VogelClinical Memory Research Unit, Department of Clinical Sciences Malmö, Lund University, Lund, Sweden; Department of Clinical Sciences, Malmö, SciLifeLab, Lund University, Lund, Sweden.
Brittany N DuggerDepartment of Pathology and Laboratory Medicine, University of California, Davis, Sacramento, CA, USA.
Hemali PhatnaniDepartment of Neurology, Columbia University, New York, NY, USA; New York Genome Center, New York, NY, USA. Electronic address: hphatnani@nygenome.org.
Funding
Topographic, cell type and molecular pathway characterization ofAlzheimer's disease using single cell transcriptomics and epigenomicsU19AG060909 · NIA · ALLEN INSTITUTE · PI Jennie Leigh Close · 2020 to 2026
$83.6MNational Alzheimer's Coordinating CenterU24AG072122 · NIA · UNIVERSITY OF WASHINGTON · PI STEPHENS, KARI A · 2021 to 2025
$45.8MResearch Education ComponentP30AG062422 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Gil Dan Rabinovici · 2019 to 2026
$36.9MUniversity of Washington Alzheimer's Disease Research CenterP30AG066509 · NIA · UNIVERSITY OF WASHINGTON · PI Amanda D. Boyd · 2020 to 2026
$29.0MResearch Education ComponentP30AG066444 · NIA · WASHINGTON UNIVERSITY · PI Susan Lynn Stark · 2020 to 2026
$28.7MPrPSc SPECIFIC INTERACTION WITH NOVEL PrP-Fc FUSION PROTEINSP50AG023501 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MILLER, BRUCE L · 2004 to 2018
$27.1MInvestigating regional and cellular vulnerabilities to tau pathology in young-onset Alzheimer's diseaseR01AG075802 · NIA · MAYO CLINIC JACKSONVILLE · PI BERNARDINO Francesco GHETTI, Lea Tenenholz Grinberg · 2022 to 2026
$15.5MData Analysis CoreU54AG076040 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI PHATNANI, HEMALI · 2021 to 2025
$13.1MThe Physical Biology of Neurodegeneration in Sporadic Amyotrophic Lateral Sclerosis/Frontotemporal DementiaR01NS127186 · NINDS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI HOLT, LIAM J, PHATNANI, HEMALI · 2021 to 2025
$8.2MFederated digital pathology platform for AD/ADRD research and diagnosticsU24NS133945 · NINDS · UNIVERSITY OF KENTUCKY · PI BUMGARDNER, CODY, FLANAGAN, MARGARET E · 2023 to 2025
$4.9MBrain Digital Slide Archive: An Open Source Platform for data sharing and analysis of digital neuropathologyU24NS133949 · NINDS · EMORY UNIVERSITY · PI Lee Cooper, Brittany Nicole Dugger · 2023 to 2026
$4.3M"What is N?" Towards operationalizing neurodegeneration in Alzheimer's and related dementiasRF1AG069052 · NIA · MAYO CLINIC ROCHESTER · PI GRAFF-RADFORD, JONATHAN, MIELKE, MICHELLE M · 2021 to 2021
$2.4MNIA NIH HHS K01 AG075177NIA NIH HHS P30 AG062422NIA NIH HHS P30 AG066444NIA NIH HHS P30 AG066509NIA NIH HHS P50 AG023501NIA NIH HHS R01 AG075802NIA NIH HHS RF1 AG069052NIA NIH HHS U19 AG060909NIA NIH HHS U24 AG072122NIA NIH HHS U54 AG076040NINDS NIH HHS R01 NS127186NINDS NIH HHS U24 NS133945NINDS NIH HHS U24 NS133949
Abstract
Transformative neuropathology is redefining human brain research by integrating foundational descriptive pathology with advanced methodologies. These approaches, spanning multi-omics studies and machine learning applications, will drive discovery for the identification of biomarkers, therapeutic targets, and complex disease patterns through comprehensive analyses of postmortem human brain tissue. Yet critical challenges remain, including the sustainability of brain banks, expanding donor participation, strengthening training pipelines, enabling rapid autopsies, supporting collaborative platforms, and integrating data across modalities. Innovations in digital pathology, tissue quality enhancement, harmonization of data standards, and machine learning integration offer opportunities to accelerate tissue-level "pathomics" research in brain health through cross-disciplinary collaborations. Lessons from neuroimaging, particularly in establishing common data frameworks and multi-site collaborations, offer a valuable roadmap for streamlining innovations. In this perspective, we outline actionable solutions for leveraging existing resources and strengthening collaboration -where we envision future opportunities to drive translational discoveries stemming from transformative neuropathology.
Indexed as
AgingBiomedical ResearchBrainNeurodegenerative DiseasesNeuropathologyHumansNeuroimagingbiomarkersdigital pathologymachine learningneuropathologypathomicsspatial biology
Identifiers
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Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.