Evidence map›Paper›PMID 40684012›Full record

ArticleMolecular diversity2026

Design, synthesis, and biological evaluation of aminopyrazine-based ATR/HDACs dual inhibitors.

Ying-Hui Yuan, Chen-Chen Wang, Ji-Long Duan, Peng-Peng Zhang, Meng-Lan He, Zhen Liu, Zi Hui, Xiang-Yang Ye

Abstract read
PubMed Publisher
In one paragraph

Article in Molecular diversity, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Design, synthesis and anti-breast cancer activity evaluation of 6,7-dihydro-5Journal of enzyme inhibition and medicinal chemistry · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Ying-Hui YuanSchool of Pharmacy, Hangzhou Normal University, Hangzhou, 311121, Zhejiang, China.
Chen-Chen WangSchool of Pharmacy, Hangzhou Normal University, Hangzhou, 311121, Zhejiang, China.
Ji-Long DuanSchool of Pharmacy, Hangzhou Normal University, Hangzhou, 311121, Zhejiang, China.
Peng-Peng ZhangSchool of Pharmacy, Hangzhou Normal University, Hangzhou, 311121, Zhejiang, China.
Meng-Lan HeSchool of Pharmacy, Hangzhou Normal University, Hangzhou, 311121, Zhejiang, China.
Zhen LiuSchool of Pharmacy, Hangzhou Normal University, Hangzhou, 311121, Zhejiang, China. zliu@hznu.edu.cn.
Zi HuiSchool of Pharmacy, Hangzhou Normal University, Hangzhou, 311121, Zhejiang, China. huizi@hznu.edu.cn.ORCID http://orcid.org/0000-0002-3211-8025
Xiang-Yang YeSchool of Pharmacy, Hangzhou Normal University, Hangzhou, 311121, Zhejiang, China. xyye@hznu.edu.cn.ORCID http://orcid.org/0000-0003-3739-0930

Funding

Hangzhou City "115" plan to introduce overseas intelligence projects 202412171Medical Health Science and Technology Project of Zhejiang Provincial Health Commission 2023KY210Science and Technology Department of Zhejiang Province 2023ZY1014
6 · The paper itself

Abstract

Ataxia telangiectasia mutated and rad3-related kinase (ATR) and histone deacetylases (HDACs) are important therapeutic targets for cancer. In this study, a series of novel ATR/HDACs dual inhibitors containing 2-aminopyrazine motifs were designed and synthesized for the first time. Compounds 18b and 18c not only exhibited good dual inhibition activity against ATR (IC

Indexed as

Antineoplastic AgentsAtaxia Telangiectasia Mutated ProteinsDrug DesignHistone Deacetylase InhibitorsHistone DeacetylasesPyrazinesApoptosisCell Line, TumorCell ProliferationHumansStructure-Activity RelationshipTubulinAntineoplastic AgentsAtaxia Telangiectasia Mutated ProteinsATR protein, humanHistone Deacetylase InhibitorsHistone DeacetylasesPyrazinesTubulinAnticancerAnti-proliferationATRDual inhibitorsHDACs

Identifiers

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.