Evidence map›Paper›PMID 40684052›Full record

ArticleEye (London, England)2025

Multimodal imaging of dark without pressure lesions in paediatric retinal vasculitis: A cross-sectional study.

Cigdem Yasar, Muhammad Hassan, Hashem Ghoraba, Christopher Or, Amir Akhavanrezayat, Jonathan Regenold, Sungwho Park, Hassan Khojasteh, Muhammad Sohail Halim, Irmak Karaca and 4 more

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Article in Eye (London, England), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Cigdem YasarSpencer Center for Vision Research, Byers Eye Institute, Stanford University, Palo Alto, CA, USA.
Muhammad HassanCincinnati Eye Institute/University of Cincinnati, Cincinnati, USA.
Hashem GhorabaSpencer Center for Vision Research, Byers Eye Institute, Stanford University, Palo Alto, CA, USA.ORCID http://orcid.org/0000-0002-1145-4134
Christopher OrSpencer Center for Vision Research, Byers Eye Institute, Stanford University, Palo Alto, CA, USA.
Amir AkhavanrezayatSpencer Center for Vision Research, Byers Eye Institute, Stanford University, Palo Alto, CA, USA.
Jonathan RegenoldSpencer Center for Vision Research, Byers Eye Institute, Stanford University, Palo Alto, CA, USA.
Sungwho ParkSpencer Center for Vision Research, Byers Eye Institute, Stanford University, Palo Alto, CA, USA.ORCID http://orcid.org/0000-0002-9186-2081
Hassan KhojastehSpencer Center for Vision Research, Byers Eye Institute, Stanford University, Palo Alto, CA, USA.
Muhammad Sohail HalimSpencer Center for Vision Research, Byers Eye Institute, Stanford University, Palo Alto, CA, USA.
Irmak KaracaSpencer Center for Vision Research, Byers Eye Institute, Stanford University, Palo Alto, CA, USA.ORCID http://orcid.org/0000-0001-7927-0887
Brandon Huy PhamSpencer Center for Vision Research, Byers Eye Institute, Stanford University, Palo Alto, CA, USA.
Gunay UludagSpencer Center for Vision Research, Byers Eye Institute, Stanford University, Palo Alto, CA, USA.
Wataru MatsumiyaSpencer Center for Vision Research, Byers Eye Institute, Stanford University, Palo Alto, CA, USA.
Quan Dong NguyenSpencer Center for Vision Research, Byers Eye Institute, Stanford University, Palo Alto, CA, USA. ndquan@stanford.edu.ORCID http://orcid.org/0000-0002-6024-8441

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo assess relationship between dark without pressure (DWP) retinopathy and retinal vasculitis (RV) in paediatric uveitis patients.

methodsThis is a retrospective cross-sectional study. Wide angle fundus photographs (WAFP), fundus autofluorescence (FAF), and optical coherence tomography (OCT) images were analysed to identify DWP retinopathy. Confluent dark areas on WAFP, hypo-autofluorescence on FAF, and EZ disruption on OCT images were the markers for DWP. DWP retinopathy area was measured using Image-J. The prevalence and characteristics of DWP in RV patients and its association with RV was reported.

resultsOut of 43 paediatric uveitis patients, 26 were diagnosed with RV. Amongst these, DWP was detected in 20 patients (30 eyes) which were analysed. Mean age was 12.8 ± 3.36 years; 40% were female. DWP areas were either diffuse, mid-peripheral or peripheral on WAFP. All 20 patients (30 eyes) showed hypo-autofluorescence on FAF at the same locations as the WAFP. The mean duration of follow-up was 27.2 ( ± 13.7) months. 12 patients (19 eyes) who had DWP at baseline visit had longer duration of uveitis compared to 8 patients (11 eyes) who developed DWP on follow-up visits (p < 0.036). Progression of the retinopathy overtime was analysed in 28 eyes; all eyes showed improvement of RV with therapy. There was a statistically significant relationship between change in vascular leakage and the change in DWP retinopathy area (chi square= 11.67, p = 0.001).

conclusionsDWP can potentially serve as a biomarker of RV in paediatric uveitis patients and its presence should warrant WAFA evaluation in this patient population.

Indexed as

Multimodal ImagingRetinal VasculitisAdolescentChildChild, PreschoolCross-Sectional StudiesFemaleFluorescein AngiographyHumansMaleRetinal VesselsRetrospective StudiesTomography, Optical CoherenceUveitis

Identifiers

PMID40684052
PMCPMC12446460

What Socratic holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.