Evidence map›Paper›PMID 40684074›Full record

Trial reportBMC geriatrics2025

Inappropriate vitamin D supplementation among multimorbid older patients: a multicountry analysis.

Elisavet Moutzouri, Shanthi Beglinger, Martin Feller, Anne Eichenberger, Olivia Dalleur, Wilma Knol, Marielle Emmelot-Vonk, Denis O'Mahony, Benoit Boland, Carole E Aubert and 4 more

Registry-linked trialAbstract readMulticenter StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in BMC geriatrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02986425 (OPERAM), which is not on this map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02986425 nacompletednot on this map

OPERAM: OPtimising thERapy to Prevent Avoidable Hospital Admissions in the Multimorbid Older People: a Cluster Randomised Controlled Trial

TypeinterventionalSponsorInsel Gruppe AG, University Hospital BernRan2016 to 2019Enrolled2,009Conditions3 or More Chronic Conditions for 6 Months or Longer, 5 or More Regular DrugsArmsSTRIP intervention, Control
3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Global under- and overprescribing of drugs-a scoping review.Naunyn-Schmiedeberg's archives of pharmacology · 2026
    Review
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Elisavet MoutzouriInstitute of Primary Health Care (BIHAM), University of Bern, Bern, Switzerland. Elisavet.moutzouri@extern.insel.ch.
Shanthi BeglingerInstitute of Primary Health Care (BIHAM), University of Bern, Bern, Switzerland.
Martin FellerInstitute of Primary Health Care (BIHAM), University of Bern, Bern, Switzerland.
Anne EichenbergerInstitute of Hospital Pharmacy, Bern University Hospital, University of Bern, Bern, Switzerland.
Olivia DalleurLouvain Drug Research Institute, Clinical Pharmacy and Pharmacoepidemiology research group, Université catholique de Louvain, Brussels, Belgium.
Wilma KnolUniversity Medical Center Utrecht, Utrecht University, Utrecht, Netherlands.
Marielle Emmelot-VonkUniversity Medical Center Utrecht, Utrecht University, Utrecht, Netherlands.
Denis O'MahonyDepartment of Medicine, University College Cork & Department of Geriatric & Stroke Medicine, Cork University Hospital, Wilton, Cork, Ireland.
Benoit BolandGeriatric, Medicine Division, Cliniques Universitaires Saint-Luc, Brussels, Belgium.
Carole E AubertInstitute of Primary Health Care (BIHAM), University of Bern, Bern, Switzerland.
Patricia O Chocano-BedoyaInstitute of Primary Health Care (BIHAM), University of Bern, Bern, Switzerland.
Drahomir AujeskyDepartment of General Internal Medicine, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
Anne SpinewineLouvain Drug Research Institute, Clinical Pharmacy and Pharmacoepidemiology research group, Université catholique de Louvain, Brussels, Belgium.
Nicolas RodondiInstitute of Primary Health Care (BIHAM), University of Bern, Bern, Switzerland.

Funding

Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung PZ00P3_201672
6 · The paper itself

Abstract

backgroundThe prevalence of vitamin D supplementation and the percentage of participants with a lack of appropriate vitamin D supplementation ("potential underuse") or potentially inappropriate vitamin D supplementation ("potential overuse") and risk factors for these are currently unclear.

methodsCross-sectional analysis from the OPERAM study, a multicenter cluster randomized controlled trial in four European countries (Belgium, Ireland, The Netherlands, Switzerland) including multimorbid (≥ 3 chronic conditions) older patients, with polypharmacy (≥ 5 chronic medications). For the definition of potential underuse and overuse we used high-risk conditions, which were defined according to the START criteria (version 2) for potential prescribing omissions in older people i.e., E2) long-term systemic corticosteroid therapy, known osteoporosis or osteopenia, E3) previous fragility fractures, and E5) housebound/in nursing homes or experiencing falls. We used mixed effect logistic regression to identify factors associated with underuse and overuse.

results2008 patients (79.4y, SD 6.3, 45% female) were included. 825/2008 (41.1%) were supplemented with vitamin D. We identified 681 participants with potential underuse (33.9% of all participants, 69.7% of non-vitamin D users) and 204 with potential overuse (10.2% of all participants, 24.7% of vitamin D users). In the multivariable logistic regression analysis increasing age and being male were associated with underuse, while the number of baseline medications and previous hospitalizations were associated with both underuse and overuse. Specifically, underuse decreased with an increasing number of medications (OR: 0.93, 95% CI: 0.90-0.95), while overuse increased (OR: 1.08, 95% CI: 1.04-1.12). Previous hospitalizations were linked to underuse (OR: 1.08, 95% CI: 1.00-1.17) and inversely associated with overuse (OR: 0.88, 95% CI: 0.77-0.99).

conclusionsOne-third of multimorbid older adults experienced potential underuse, while up to 10% potential overuse of vitamin D supplementation. Polypharmacy, previous hospitalizations, increasing age and being male are factors associated with inappropriate use of vitamin D. A better targeted vitamin D supplementation is warranted.

trial registrationNCT02986425, Registration date 2016-10-21.

Indexed as

Dietary SupplementsInappropriate PrescribingMultimorbidityVitamin DAgedAged, 80 and overBelgiumCross-Sectional StudiesEuropeFemaleHumansMalePolypharmacyRisk FactorsVitamin DInappropriate prescribingOlder adultsOveruseVitamin D

Identifiers

PMID40684074
PMCPMC12275266

What Socratic holds

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LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.