Observational studyBMC cardiovascular disorders2025
Prognostic value of hemoglobin, albumin, lymphocyte, platelet (HALP) scores in patients with non-valvular atrial fibrillation: insights from the AFTER-2 study.
Observational study in BMC cardiovascular disorders, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Review
- Comparative predictive performance of HALP score and prognostic nutritional index for mortality in ICU patients after hip fracture surgery.BMC geriatrics · 2026Article
- Emergency department evaluation of immature granulocytes for complicated acute appendicitis: a retrospective cohort study.Ulusal travma ve acil cerrahi dergisi = Turkish journal of trauma & emergency surgery : TJTES · 2026Article
- Prognostic value of the HALP score in patients undergoing emergency surgery for gastroduodenal perforation.Ulusal travma ve acil cerrahi dergisi = Turkish journal of trauma & emergency surgery : TJTES · 2026Article
- HALP score adds prognostic information beyond STS for 2-year mortality after transcatheter aortic valve implantation: a two-center retrospective cohort study.BMC cardiovascular disorders · 2026Article
- Prognostic Value of HALP Score in Rheumatic Mitral Stenosis: A Long-Term Follow-Up Study.Clinical cardiology · 2026Article
- Association between prognostic nutritional index and major adverse cardiovascular events in patients with atrial fibrillation combined with heart failure with preserved ejection fraction.Frontiers in nutrition · 2026Article
- Prognostic value of objective nutritional indices (PNI, CONUT, and HALP) for in-hospital all-cause mortality in surgically treated infective endocarditis: a 14-year retrospective study in a Chinese cohort.Frontiers in nutrition · 2026Article
- Correlation of Controlling Nutritional Status Score and Systemic Immune-Inflammation Index With Frailty and Prognosis in Chronic Heart Failure Patients With Atrial Fibrillation.Cardiology research and practice · 2026Article
- Prognostic significance of the CALLY index for cancer risk and survival: evidence from NHANES 2001-2018.World journal of surgical oncology · 2025Article
- Monocyte-to-lymphocyte ratio as a predictor of left ventricular aneurysm in acute STEMI patients.Frontiers in endocrinology · 2025Article
- Clinical Relevance of HALP Score in Predicting Hospital Stay Duration and Outcomes in Acute Heart Failure.International journal of general medicine · 2025Article
- Comparison of PNI, HALP, and modified HALP scores in predicting 90-day mortality in elderly patients with acute ischemic stroke.Frontiers in neurologyArticle
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13 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesThe relationship between hemoglobin, albumin, lymphocyte, platelet (HALP) score, and various cancers and cardiovascular diseases has been tested previously. However, the relationship between HALP score and non-valvular atrial fibrillation (NVAF) has not been adequately tested. Therefore, our study aimed to investigate the relationship between HALP score and mortality in patients with NVAF.
methodsThis study included 2,592 NVAF patients from 35 centers in Turkey. Patients were divided into two groups: those with HALP scores ≤ 58.96 (low HALP score group, 1,296 patients) and > 58.96 (high HALP score group, 1,296 patients). The primary outcome measured was all-cause mortality.
resultsThe mean HALP score was 66 ± 33. Patients in the low HALP score group had higher 1- and 5-year all-cause mortality rates (1-year: 12.9% vs. 5.4%, p < 0.001; 5-year: 38.5% vs. 20.2%, p < 0.001). Cox regression analysis identified the HALP score as an independent predictor of mortality (1-year: HR = 0.987, 95% CI = 0.981-0.992, p < 0.001; 5-year: HR = 0.990, 95% CI = 0.987-0.993, p < 0.001). ROC analysis determined a HALP score 52.3 predicted 1-year mortality with 62.9% sensitivity and 62% specificity (AUC = 0.680); a score of 55 predicted 5-year mortality with 60.3% sensitivity and 62.2% specificity (AUC = 0.657). Kaplan-Meier analysis revealed increasing mortality over time in the low HALP score group (log-rank tests, 1-year = 44.86, p < 0.001; 5-year = 108.54, p < 0.001).
conclusionsThe HALP score is a simple, accessible measure, and our findings suggest that lower HALP scores are associated with increased 1-year and 5-year mortality in NVAF patients. This provides a reference for clinicians assessing risk in this vulnerable population.
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