ArticleLipids in health and disease2025
High-density lipoprotein cholesterol, particles and subspecies and the risk of chronic kidney disease: The PREVEND prospective study.
Article in Lipids in health and disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- TGL / HDL - C ratio and non-HDL-C - prognostic index in chronic kidney disease.Bioinformation · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe relationships between high-density lipoprotein cholesterol (HDL-C), HDL particle concentration (HDL-P), and HDL subspecies with the development of chronic kidney disease (CKD) have not been well characterized. This study aimed to examine these associations and evaluate the role of alcohol consumption as a potential confounder or effect modifier.
methodsData was analyzed from 4,179 individuals (mean age: 52 years; 47.6% male) participating in the PREVEND cohort. Baseline measurements included HDL-P and its subfractions (small, medium, and large), quantified by nuclear magnetic resonance spectroscopy, and self-reported alcohol intake. Incident CKD was defined using criteria from the KDIGO guidelines. Cox proportional hazards models were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) for each HDL metric per 1 standard deviation (SD) increment.
resultsOver a median follow-up of 8.3 years, 565 participants developed CKD. After adjusting for multiple confounders, including alcohol use, HDL-P, medium HDL, and H3P showed modest inverse associations with CKD risk, with adjusted HRs (95% CIs) of 0.90 (0.83-0.98), 0.91 (0.83-1.00), and 0.90 (0.82-0.99), respectively. Conversely, H7P was positively associated with CKD risk (HR 1.11, 95% CI: 1.00-1.22). Significant interactions with sex were observed for medium HDL, small HDL, and H1P. Alcohol intake neither significantly modified the associations nor showed a direct relationship with CKD risk.
conclusionsThis study suggests distinct associations of HDL parameters with CKD risk as well as sex differences in the associations of these parameters with CKD risk. The findings underscore the heterogeneity of HDL subspecies and the need to consider sex-specific differences in future studies. Alcohol consumption had no impact on these associations.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.