ArticleObesity (Silver Spring, Md.)2025
Early meal timing attenuates high polygenic risk of obesity.
Article in Obesity (Silver Spring, Md.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
5 citing papers in PubMed.
- Chrononutrition and cardiometabolic health: circadian timing as a dimension of precision nutrition.Frontiers in nutrition · 2026Review
- Temporal meal patterns in relation to diet quality and body mass index: findings from a cross-sectional analysis.European journal of nutrition · 2025Article
- Nutrigenomics meets multi-omics: integrating genetic, metabolic, and microbiome data for personalized nutrition strategies.Genes & nutrition · 2025Review
- Early meal timing attenuates high polygenic risk of obesity.Obesity (Silver Spring, Md.) · 2025Article
- Timing Matters: Early Eating Mitigates Genetic Susceptibility for Obesity.Obesity (Silver Spring, Md.) · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
objectiveWe examined whether meal timing is associated with long-term weight-loss maintenance and whether meal timing interacts with a genome-wide polygenic score (PRS-BMI) on body weight-related outcomes. We then examined the interaction of meal timing with 97 BMI-related single-nucleotide polymorphisms on obesity outcome.
methodsParticipants (N = 1195, mean age 41.07 [SD 12.68] years, female 80.8%, baseline mean BMI 31.32 [SD 5.53] kg/m
resultsEach hour of delay in meal timing was associated with 2.2% higher long-term body weight (β [SE] = 2.177% [1.067%]; p = 0.042) (i.e., with lower weight-loss maintenance following dietary obesity treatment). There was a significant interaction between meal timing and PRS-BMI (p = 0.008); BMI increased by more than 2 kg/m
conclusionsMeal timing is associated with weight-loss maintenance and may influence the association between obesity genetics and BMI. Findings underscore the importance of personalized obesity management.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.