Evidence map›Paper›PMID 40685570›Full record

ReviewJournal of feline medicine and surgery2025

Osteoarthritis in cats: what we know, and mostly, what we don't know. . . yet.

Manuela Lefort-Holguin, Aliénor Delsart, Marilyn Frézier, Laurie Martin, Colombe Otis, Maxim Moreau, Aude Castel, Bertrand Lussier, Johanne Martel-Pelletier, Jean-Pierre Pelletier and 1 more

Abstract readReview
In one paragraph

Review in Journal of feline medicine and surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Guideline
  2. Trial
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Pain and pain management in cats: an ever-evolving field.Journal of feline medicine and surgery · 2025
    Article
  9. Article
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Manuela Lefort-HolguinGroupe de Recherche en Pharmacologie Animale du Québec (GREPAQ), Université de Montréal, Saint-Hyacinthe, QC, Canada.
Aliénor DelsartGroupe de Recherche en Pharmacologie Animale du Québec (GREPAQ), Université de Montréal, Saint-Hyacinthe, QC, Canada.
Marilyn FrézierGroupe de Recherche en Pharmacologie Animale du Québec (GREPAQ), Université de Montréal, Saint-Hyacinthe, QC, Canada.
Laurie MartinGroupe de Recherche en Pharmacologie Animale du Québec (GREPAQ), Université de Montréal, Saint-Hyacinthe, QC, Canada.
Colombe OtisGroupe de Recherche en Pharmacologie Animale du Québec (GREPAQ), Université de Montréal, Saint-Hyacinthe, QC, Canada.ORCID 0000-0003-4286-6534
Maxim MoreauGroupe de Recherche en Pharmacologie Animale du Québec (GREPAQ), Université de Montréal, Saint-Hyacinthe, QC, Canada.
Aude CastelGroupe de Recherche en Pharmacologie Animale du Québec (GREPAQ), Université de Montréal, Saint-Hyacinthe, QC, Canada.
Bertrand LussierGroupe de Recherche en Pharmacologie Animale du Québec (GREPAQ), Université de Montréal, Saint-Hyacinthe, QC, Canada.ORCID 0000-0001-7319-3841
Johanne Martel-PelletierGroupe de Recherche en Pharmacologie Animale du Québec (GREPAQ), Université de Montréal, Saint-Hyacinthe, QC, Canada.ORCID 0000-0003-2618-383X
Jean-Pierre PelletierGroupe de Recherche en Pharmacologie Animale du Québec (GREPAQ), Université de Montréal, Saint-Hyacinthe, QC, Canada.ORCID 0000-0001-9930-6453
Eric TroncyGroupe de Recherche en Pharmacologie Animale du Québec (GREPAQ), Université de Montréal, Saint-Hyacinthe, QC, Canada.ORCID 0000-0003-0209-5261

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Osteoarthritis (OA) is a degenerative joint disease that is considered the primary source of chronic pain in cats, affecting well over a quarter of the feline population. Despite its prevalence, detection and diagnosis rates remain low, as many owners are unaware of the signs of feline OA. There is limited knowledge regarding the management of feline OA, with only 29 publications available, many of which lack rigorous methodology. Furthermore, most research focuses on the efficacy of non-steroidal anti-inflammatory drugs, while proposed alternatives to alleviate feline OA pain - such as food restriction, weight loss, adjunctive musculoskeletal treatments with biologics, physiotherapeutic modalities and lifestyle changes - are primarily based on human clinical studies and veterinary research on other species, which introduces a high risk of bias. New promising avenues are being explored with anti-nerve growth factor monoclonal antibodies; however, the long-term effects of repetitive administration, optimal conditions for administration and specific indications have yet to be described. Research from the

Indexed as

Cat DiseasesOsteoarthritisAnimalsAnti-Inflammatory Agents, Non-SteroidalCatsAnti-Inflammatory Agents, Non-Steroidalchronic pain managementDegenerative joint diseasedetectiondiagnosisnon-pharmacologicalpharmaceuticaltherapeutic efficacy

Identifiers

PMID40685570
PMCPMC12277680

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.