Evidence map›Paper›PMID 40685600›Full record

Trial reportRespirology (Carlton, Vic.)2025

Clinical Features Associated With Fatigue in People With Fibrotic Interstitial Lung Disease: Cross-Sectional Study.

Shohei Kawachi, Mariana Hoffman, Anne E Holland

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Respirology (Carlton, Vic.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03737409 (PFOX), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03737409 nacompletednot on this map

PFOX: Pulmonary Fibrosis Ambulatory Oxygen Trial

TypeinterventionalSponsorMonash UniversityRan2019 to 2024Enrolled116ConditionsFibrotic Interstitial Lung DiseaseArmsAmbulatory Oxygen Therapy, Sham Ambulatory Oxygen Therapy
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Trial
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Shohei KawachiRespiratory Research@Alfred, School of Translational Medicine, Monash University, Melbourne, Victoria, Australia.ORCID 0000-0002-5093-5125
Mariana HoffmanRespiratory Research@Alfred, School of Translational Medicine, Monash University, Melbourne, Victoria, Australia.
Anne E HollandRespiratory Research@Alfred, School of Translational Medicine, Monash University, Melbourne, Victoria, Australia.ORCID 0000-0003-2061-845X

Funding

National Health and Medical Council (Australia) GNT1139953
6 · The paper itself

Abstract

BACKGROUND AND

objectiveFatigue significantly impacts quality of life in fibrosing interstitial lung diseases (fILDs). Oxyhaemoglobin desaturation contributes to fatigue in chronic obstructive pulmonary disease; however, this has not been investigated in fILD. This study aimed to elucidate the relationship between fatigue and clinical features, including oxyhaemoglobin desaturation, in fILD.

methodsParticipants had stable fILD with exertional desaturation (SpO

resultsOne hundred and sixteen participants were included with mean (SD) age of 70.9 (9.8), FVC% of 69.8 (16.1). Seventy-two participants (62%) had substantial fatigue (≥ 36 on FSS). Univariate analysis showed no relationship between FSS and nadir SpO

conclusionDyspnoea and physical activity are associated with fatigue in fILD. Exertional desaturation does not appear to contribute to fatigue in this group.

trial registrationClinicalTrials.gov Registry (URL: https://clinicaltrials.gov/study/NCT03737409).

Indexed as

FatigueLung Diseases, InterstitialPulmonary FibrosisAgedCross-Sectional StudiesDyspneaFemaleHumansMaleMiddle AgedOxyhemoglobinsQuality of LifeSecondary Data AnalysisSeverity of Illness IndexWalk TestOxyhemoglobinsdesaturationdyspnoeafatiguehypoxaemiahypoxiainterstitial lung diseasesphysical inactivity

Identifiers

PMID40685600
PMCPMC12581090

What Socratic holds

Textmetadata
LicenceCC BY-NC
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.