Evidence map›Paper›PMID 40685947›Full record

ReviewChemistryOpen2025

Electrochemical and Nanomaterial-Based Strategies for Nonenzymatic Glucose Detection: A Review.

Reagan Aviha, Gymama Slaughter

Abstract readReview
In one paragraph

Review in ChemistryOpen, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Reagan AvihaCenter for Bioelectronics, Old Dominion University, Norfolk, Virginia, 23508, USA.
Gymama SlaughterCenter for Bioelectronics, Old Dominion University, Norfolk, Virginia, 23508, USA.ORCID 0000-0002-4307-091X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Electrochemical glucose sensing technologies have undergone significant evolution, with continual advancements aimed at improving sensitivity, selectivity, and user convenience. This review systematically explores the development of emerging nonenzymatic glucose sensor designs. Nonenzymatic sensors are critically evaluated for their ability to overcome enzymatic limitations, leveraging novel materials and catalytic mechanisms. Additionally, the emergence of smartphone-integrated glucose monitoring systems is highlighted as the fifth generation, representing a paradigm shift toward personalized, real-time healthcare management. Emphasis is placed on the strategies employed to reduce the working electrode potential and enhance analytical performance. Key analytical metrics and real-sample applicability are evaluated, and persistent challenges including reliability, biocompatibility, and calibration-free operation are identified. Further, this review provides a critical perspective on the trajectory of electrochemical nonenzymatic glucose sensor technologies and outlines future directions toward the development of next-generation platforms for continuous and noninvasive glucose monitoring.

Indexed as

Biosensing TechniquesBlood GlucoseElectrochemical TechniquesGlucoseNanostructuresElectrodesHumansBlood GlucoseGlucoseglucose biosensorsnonenzymaticsmartphone‐integrated

Identifiers

PMID40685947
PMCPMC12598812

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.