Evidence map›Paper›PMID 40687176›Full record

ArticleJournal of Alzheimer's disease reports

Cognitive impairment in cerebellar phenotype of multiple system atrophy and its association with hot-cross bun sign.

Wenxiang Liao, Danlei Chen, Yuyuan Huang, Keliang Chen, Mengmeng Li, Zhiqiang Han, Shirong Wei, Fangfang Xie, Fei Lv, Jintai Yu and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of Alzheimer's disease reports. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Wenxiang LiaoDepartment of Neurology, Huashan Hospital, Fudan University, Shanghai, China.
Danlei ChenDepartment of Geriatrics, The First Affiliated Hospital of Guilin Medical University, Guilin, Guangxi, China.
Yuyuan HuangDepartment of Neurology, Huashan Hospital, Fudan University, Shanghai, China.
Keliang ChenDepartment of Neurology, Huashan Hospital, Fudan University, Shanghai, China.
Mengmeng LiDepartment of Neurology, Huashan Hospital, Fudan University, Shanghai, China.
Zhiqiang HanDepartment of Neurology, The First Affiliated Hospital of Guilin Medical University, Guilin, Guangxi, China.
Shirong WeiDepartment of Neurology, Graduate College of Guilin Medical University, Guilin, Guangxi, China.
Fangfang XieDepartment of Neurology, Graduate College of Guilin Medical University, Guilin, Guangxi, China.
Fei LvDepartment of Neurology, Graduate College of Guilin Medical University, Guilin, Guangxi, China.
Jintai YuDepartment of Neurology, Huashan Hospital, Fudan University, Shanghai, China.
Shufen ChenDepartment of Neurology, Huashan Hospital, Fudan University, Shanghai, China.
Mei CuiDepartment of Neurology, Huashan Hospital, Fudan University, Shanghai, China.
Qianhua ZhaoDepartment of Neurology, Huashan Hospital, Fudan University, Shanghai, China.ORCID https://orcid.org/0000-0001-5655-158X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Cognitive impairment has been reported in patients with cerebellar phenotype of multiple system atrophy (MSA-C), yet this area remains largely unexplored. Objective: We evaluated the cognitive profile of MSA-C patients and assessed its association with neuroimaging features, specifically the hot-cross bun (HCB) sign. Methods: This retrospective study encompassed 210 patients diagnosed with MSA-C between 2019 and 2023. Each patient underwent a thorough clinical evaluation, a comprehensive neuropsychological assessment and a magnetic resonance imaging (MRI) scan. Results: MSA-C patients demonstrated a high burden of comorbidities, including a high frequency of motor symptoms, autonomic disorders, and various non-motor symptoms such as cognitive deficits, mood disorders and sleep disturbances. Notably, 24.8% of MSA-C patients exhibited cognitive impairment, primarily affecting language, memory and processing speed. The presence of the HCB sign was independently associated with cognitive impairment, whereas other clinical features, such as orthostatic hypotension, were not. MSA-C patients with the HCB sign demonstrated significantly poorer performance in language, visuospatial function, and processing speed. Conclusions: MSA-C patients suffer a substantial burden of cognitive impairment, primarily affecting language, memory and processing speed. Notably, the HCB sign is a significant indicator for cognitive dysfunction in patients with MSA-C.

Indexed as

Alzheimer’s diseasecognitive impairmenthot-cross bun signmultiple system atrophyorthostatic hypotension

Identifiers

PMID40687176
PMCPMC12276462

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.