ArticleTranslational cancer research2025
Pre-radiotherapy frailty and associated determinants in elderly patients with thoracic tumors.
Article in Translational cancer research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Risk factors for frailty in older adults with cancer: a systematic review.BMC geriatrics · 2026Pooled it
- Prevalence and influencing factors of oral frailty in cancer patients: a systematic review and meta-analysis.Frontiers in public health · 2026Pooled it
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Elderly patients with thoracic tumors, including lung, esophageal, or mediastinal malignancies, encounter distinct challenges when undergoing radiotherapy (RT) due to age-related frailty. Research has identified several factors that influence RT outcomes in this patient population. These factors encompass age, comorbidities, polypharmacy, types and duration of physical activity, albumin levels, psychological distress, and sleep disorders. The objective of this study was to offer a reference for the management and intervention of frailty in patients with tumors. Methods: The Chinese version of the Tilburg Frailty Index, known as the General Information Questionnaire and the Oral Frailty Screening Scale were used to assess 139 patients aged 60 years and above who were scheduled to undergo RT for thoracic tumors at Zhejiang Cancer Hospital. Multiple linear regression analysis was used to identify the factors influencing pre-RT frailty in these patients. Results: Among the pre-RT patients with thoracic tumors included in this study, 28.1% were classified as frail, with an overall frailty score of 3.75±2.429. This encompassed social frailty (1.56±0.772), psychological frailty (0.68±0.965), physical frailty (1.51±1.525), and oral frailty (3.38±1.987). The primary factors influencing pre-RT frailty in elderly patients with thoracic tumors were age, comorbidities, multiple medications, exercise type and duration, albumin levels, psychological distress, and sleep disturbances. Conclusions: Elderly patients with thoracic tumors exhibit varying degrees of frailty across physical, social, psychological, and oral dimensions, with social and psychological frailty being particularly prominent. Elderly patients who were of advanced age, with multiple chronic diseases, taking multiple medications, engaging in limited resistance exercise, and having low albumin levels are especially vulnerable to frailty. Healthcare providers should prioritize the assessment of frailty in these patients and promptly implement comprehensive and feasible interventions to prevent or mitigate the onset and progression of frailty.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.