Evidence map›Paper›PMID 40687705›Full record

ArticleFrontiers in medicine2025

Baseline predictors for 28-day COVID-19 severity and mortality among hospitalized patients: results from the IMPACC study.

Jintong Hou, Benjamin Haslund-Gourley, Joann Diray-Arce, Annmarie Hoch, Nadine Rouphael, Patrice M Becker, Alison D Augustine, Al Ozonoff, Leying Guan, Steven H Kleinstein and 44 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

54 authors.

Jintong HouDepartment of Microbiology and Immunology/Department of Medicine/Department of Epidemiology & Biostatistics, Drexel University, Philadelphia, PA, United States.
Benjamin Haslund-GourleyDepartment of Microbiology and Immunology/Department of Medicine/Department of Epidemiology & Biostatistics, Drexel University, Philadelphia, PA, United States.
Joann Diray-ArceClinical and Data Coordinating Center (CDCC) Precision Vaccines Program, Boston Children's Hospital, Boston, MA, United States.
Annmarie HochClinical and Data Coordinating Center (CDCC) Precision Vaccines Program, Boston Children's Hospital, Boston, MA, United States.
Nadine RouphaelEmory School of Medicine, Atlanta, GA, United States.
Patrice M BeckerNational Institute of Allergy and Infectious Diseases, National Institute of Health, Bethesda, MD, United States.
Alison D AugustineNational Institute of Allergy and Infectious Diseases, National Institute of Health, Bethesda, MD, United States.
Al OzonoffClinical and Data Coordinating Center (CDCC) Precision Vaccines Program, Boston Children's Hospital, Boston, MA, United States.
Leying GuanYale School of Public Health, and Yale School of Medicine, New Haven, CT, United States.
Steven H KleinsteinYale School of Public Health, and Yale School of Medicine, New Haven, CT, United States.
Bjoern PetersLa Jolla Institute for Immunology, La Jolla, CA, United States.
Elaine ReedDavid Geffen School of Medicine at the University of California Los Angeles, Los Angeles, CA, United States.
Matt AltmanDepartment of Medicine, Benaroya Research Institute, University of Washington, Seattle, WA, United States.
Charles R LangelierSchool of Medicine, University of California San Francisco, San Francisco, CA, United States.
Holden MaeckerStanford University School of Medicine, Palo Alto, CA, United States.
Seunghee KimIcahn School of Medicine at Mount Sinai, New York, NY, United States.
Ruth R MontgomeryYale School of Public Health, and Yale School of Medicine, New Haven, CT, United States.
Florian KrammerStanford University School of Medicine, Palo Alto, CA, United States.
Michael WilsonSchool of Medicine, University of California San Francisco, San Francisco, CA, United States.
Walter EckalbarSchool of Medicine, University of California San Francisco, San Francisco, CA, United States.
Steven E BosingerEmory School of Medicine, Atlanta, GA, United States.
Ofer LevyPrecision Vaccines Program, Boston Children's Hospital, Harvard Medical School, Boston, MA, United States.
Hanno SteenPrecision Vaccines Program, Boston Children's Hospital, Harvard Medical School, Boston, MA, United States.
Lindsey B RosenNational Institute of Allergy and Infectious Diseases, National Institute of Health, Bethesda, MD, United States.
Lindsey R BadenBrigham and Women's Hospital, Harvard Medical School, Boston, MA, United States.
Esther MelamedDepartment of Neurology/Department of Molecular Biosciences, University of Texas, Austin, TX, United States.
Lauren I R EhrlichDepartment of Neurology/Department of Molecular Biosciences, University of Texas, Austin, TX, United States.
Grace A McComseyCase Western Reserve University and University Hospitals of Cleveland, Cleveland, OH, United States.
Rafick P SekalyCase Western Reserve University and University Hospitals of Cleveland, Cleveland, OH, United States.
Joanna SchaenmanDavid Geffen School of Medicine at the University of California Los Angeles, Los Angeles, CA, United States.
Albert C ShawYale School of Public Health, and Yale School of Medicine, New Haven, CT, United States.
David A HaflerYale School of Public Health, and Yale School of Medicine, New Haven, CT, United States.
David B CorryBaylor College of Medicine and the Center for Translational Research on Inflammatory Diseases, Houston, TX, United States.
Farrah KheradmandBaylor College of Medicine and the Center for Translational Research on Inflammatory Diseases, Houston, TX, United States.
Mark A AtkinsonDepartment of Pathology, Immunology and Laboratory Medicine/Department of Surgery, University of Florida, Gainesville, FL, United States.
Scott C BrakenridgeDepartment of Pathology, Immunology and Laboratory Medicine/Department of Surgery, University of Florida, Gainesville, FL, United States.
Nelson I Agudelo HiguitaOklahoma University Health Sciences Center, Oklahoma City, OK, United States.
Jordan P MetcalfOklahoma University Health Sciences Center, Oklahoma City, OK, United States.
Catherine L HoughDepartment of Medicine, Oregon Health Sciences University, Portland, OR, United States.
William B MesserDepartment of Medicine, Oregon Health Sciences University, Portland, OR, United States.
Bali PulendranStanford University School of Medicine, Palo Alto, CA, United States.
Kari C NadeauStanford University School of Medicine, Palo Alto, CA, United States.
Mark M DavisStanford University School of Medicine, Palo Alto, CA, United States.
Ana Fernandez SesmaIcahn School of Medicine at Mount Sinai, New York, NY, United States.
Viviana SimonIcahn School of Medicine at Mount Sinai, New York, NY, United States.
Monica KraftDepartment of Medicine, University of Arizona, Tucson, AZ, United States.
Chris BimeDepartment of Medicine, Oregon Health Sciences University, Portland, OR, United States.
Carolyn S CalfeeSchool of Medicine, University of California San Francisco, San Francisco, CA, United States.
David J ErleSchool of Medicine, University of California San Francisco, San Francisco, CA, United States.
Impacc NetworkDepartment of Microbiology and Immunology/Department of Medicine/Department of Epidemiology & Biostatistics, Drexel University, Philadelphia, PA, United States.
Lucy F RobinsonDepartment of Microbiology and Immunology/Department of Medicine/Department of Epidemiology & Biostatistics, Drexel University, Philadelphia, PA, United States.
Charles B CairnsDepartment of Microbiology and Immunology/Department of Medicine/Department of Epidemiology & Biostatistics, Drexel University, Philadelphia, PA, United States.
Elias K HaddadDepartment of Microbiology and Immunology/Department of Medicine/Department of Epidemiology & Biostatistics, Drexel University, Philadelphia, PA, United States.
Mary Ann ComunaleDepartment of Microbiology and Immunology/Department of Medicine/Department of Epidemiology & Biostatistics, Drexel University, Philadelphia, PA, United States.

Funding

Understanding Influenza and SARS-CoV-2 vaccine responses, in vivo and in vitroU19AI057229 · STANFORD UNIVERSITY · 2003 to 2025
$10.0M
Systems investigation of vaccine responses in B cell depleted autoimmune patientsU19AI089992 · YALE UNIVERSITY · 2025 to 2025
$2.5M
Systems biological assessment of T cell responses to vaccinationU19AI167903 · STANFORD UNIVERSITY · 2025 to 2025
$2.2M
Distinct contributions of CCR4 versus CCR7 to thymocyte localization and central toleranceR01AI104870 · NIAID · UNIVERSITY OF TEXAS AT AUSTIN · 2024 to 2025
$1.1M
Long Term Immunity Following Yellow Fever VaccinationR01AI145835 · NIAID · OREGON HEALTH & SCIENCE UNIVERSITY · PI William Messer · 2023 to 2023
$525k
NIAID NIH HHS R01 AI104870NIAID NIH HHS R01 AI145835NIAID NIH HHS U19 AI057229NIAID NIH HHS U19 AI089992NIAID NIH HHS U19 AI167903NIAID NIH HHS U54 AI142766
6 · The paper itself

Abstract

Introduction: The coronavirus disease 2019 (COVID-19) pandemic threatened public health and placed a significant burden on medical resources. The Immunophenotyping Assessment in a COVID-19 Cohort (IMPACC) study collected clinical, demographic, blood cytometry, serum receptor-binding domain (RBD) antibody titers, metabolomics, targeted proteomics, nasal metagenomics, Olink, nasal viral load, autoantibody, SARS-CoV-2 antibody titers, and nasal and peripheral blood mononuclear cell (PBMC) transcriptomics data from patients hospitalized with COVID-19. The aim of this study is to select baseline biomarkers and build predictive models for 28-day in-hospital COVID-19 severity and mortality with most predictive variables while prioritizing routinely collected variables. Methods: We analyzed 1102 hospitalized COVID-19 participants. We used the lasso and forward selection to select top predictors for severity and mortality, and built predictive models based on balanced training data. We then validated the models on testing data. Results: Severity was best predicted by the baseline SpO Conclusion: This study identifies clinical data and laboratory biomarkers of COVID-19 severity and mortality using machine learning models. The study identifies SpO

Indexed as

COVID-19FGF23machine learningmortalityribitolseveritySpO2/FiO2TNFRSF11B

Identifiers

PMID40687705
PMCPMC12271175

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.