Evidence map›Paper›PMID 40687835›Full record

ArticleiScience2025

Acute alcohol in prefrontal cortex is characterized by enhanced inhibition that transitions to excitation.

Kathleen G Bryant, David Swygart, Yuexi Yin, Meredith R Bauer, Mitchell D Morningstar, Nicholas M Timme, William H Barnett, Colleen E McGonigle, Eric A Engleman, Patrick L Sheets and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Kathleen G BryantDepartment of Anatomy, Cell Biology, and Physiology, Indiana University School of Medicine, Indianapolis, IN, USA.
David SwygartDepartment of Anatomy, Cell Biology, and Physiology, Indiana University School of Medicine, Indianapolis, IN, USA.
Yuexi YinStark Neuroscience Research Institute, Indianapolis School of Medicine, Indianapolis, IN, USA.
Meredith R BauerDepartment of Psychology, Indiana University Indianapolis, Indianapolis, IN, USA.
Mitchell D MorningstarDepartment of Psychology, Indiana University Indianapolis, Indianapolis, IN, USA.
Nicholas M TimmeDepartment of Pharmacology and Systems Physiology, University of Cincinnati, Cincinnati, OH, USA.
William H BarnettDepartment of Anatomy, Cell Biology, and Physiology, Indiana University School of Medicine, Indianapolis, IN, USA.
Colleen E McGonigleDepartment of Anatomy, Cell Biology, and Physiology, Indiana University School of Medicine, Indianapolis, IN, USA.
Eric A EnglemanStark Neuroscience Research Institute, Indianapolis School of Medicine, Indianapolis, IN, USA.
Patrick L SheetsStark Neuroscience Research Institute, Indianapolis School of Medicine, Indianapolis, IN, USA.
Christopher C LapishDepartment of Anatomy, Cell Biology, and Physiology, Indiana University School of Medicine, Indianapolis, IN, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Acute alcohol can have profound effects on the brain and behavior. Dorsal medial prefrontal cortex (dmPFC) function is especially sensitive to disruption from acute alcohol exposure. The acute, broadly inhibitory pharmacodynamics of alcohol in dmPFC have been well characterized in

Indexed as

NeuroscienceSensory neuroscience

Identifiers

PMID40687835
PMCPMC12270941

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.