Evidence mapPaperPMID 40688016Full record

ReviewBioactive materials2025

Emerging biomedical engineering strategies for hair follicle regeneration.

Xinyue Cao, Minhui Lu, Ning Li, Lijun Cai, Yu Wang, Yuanjin Zhao

Abstract readReview
In one paragraph

Review in Bioactive materials, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Xinyue CaoDepartment of Rheumatology and Immunology, Nanjing Drum Tower Hospital, School of Biological Science and Medical Engineering, Southeast University, Nanjing, 210096, China.
Minhui LuDepartment of Rheumatology and Immunology, Nanjing Drum Tower Hospital, School of Biological Science and Medical Engineering, Southeast University, Nanjing, 210096, China.
Ning LiDepartment of Rheumatology and Immunology, Nanjing Drum Tower Hospital, School of Biological Science and Medical Engineering, Southeast University, Nanjing, 210096, China.
Lijun CaiDepartment of Rheumatology and Immunology, Nanjing Drum Tower Hospital, School of Biological Science and Medical Engineering, Southeast University, Nanjing, 210096, China.
Yu WangDepartment of Rheumatology and Immunology, Nanjing Drum Tower Hospital, School of Biological Science and Medical Engineering, Southeast University, Nanjing, 210096, China.
Yuanjin ZhaoDepartment of Rheumatology and Immunology, Nanjing Drum Tower Hospital, School of Biological Science and Medical Engineering, Southeast University, Nanjing, 210096, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hair follicle undergoes cyclical regeneration that relies on the spatiotemporal coordination of epithelial-mesenchymal interactions and multiple signaling pathways. However, hair follicle homeostasis is susceptible to disruption by various endogenous and exogenous factors, leading to hair loss diseases like androgenetic alopecia and scarring alopecia. Traditional pharmacological treatments and surgical transplantation still face challenges in meeting clinical demands because of unstable therapeutic efficacy, limited donor resources, and postoperative complications. In this condition, biomedical engineering has advanced hair follicle regeneration from "replacement therapy" to "functional reconstruction" by integrating interdisciplinary approaches such as stem cell technology, tissue engineering, and modern engineering technology. This review systematically summarizes the latest advancements in biomedical engineering technology in the realm of hair follicle regeneration. We first elucidate hair follicles' structure, cyclic regulatory mechanisms, and main impact factors. Subsequently, we evaluate the advanced

Indexed as

Biomedical strategiesHair follicle regenerationOrganoidStem cellTissue engineering

Identifiers

PMID40688016
PMCPMC12274855

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.