Evidence map›Paper›PMID 40688020›Full record

ArticleBioactive materials2025

Stromal-platelet membrane-inspired nanoparticles (SPIN) for targeted heart repair.

Mingqian He, Yuan Li, Dashuai Zhu, Junlang Li, Meggie Cangu, Panagiotis Tasoudis, Jiazhu Xu, Thomas G Caranasos, Yi Hong, Ke Huang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioactive materials, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Mingqian HeDepartment of Biomedical Engineering, University of North Carolina Chapel Hill and NC State University, North Carolina, USA.
Yuan LiDepartment of Biomedical Engineering, Columbia University, New York, USA.
Dashuai ZhuDepartment of Biomedical Engineering, Columbia University, New York, USA.
Junlang LiSmidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Meggie CanguDepartment of Biological Sciences, North Carolina State University, Raleigh, NC, USA.
Panagiotis TasoudisDivision of Cardiothoracic Surgery, the University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Jiazhu XuDepartment of Bioengineering, University of Texas at Arlington, Arlington, USA.
Thomas G CaranasosDepartment of Biological Sciences, North Carolina State University, Raleigh, NC, USA.
Yi HongDepartment of Bioengineering, University of Texas at Arlington, Arlington, USA.
Ke HuangDepartment of Pharmaceutical Sciences, Texas A&M University, Kingsville, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Myocardial infarction (MI), commonly known as a heart attack, remains a leading cause of death worldwide. Standard treatments, such as coronary stent placement or coronary artery bypass graft surgery, aim to restore blood flow to ischemic myocardial tissue. However, a significant complication of these procedures is ischemia/reperfusion (I/R) injury, which occurs when blood flow is restored, triggering oxidative stress, inflammation, and calcium overload that can further damage the heart. To limit the I/R injury following the coronary recanalization of an MI heart, we designed stromal-platelet membrane-inspired nanoparticles (SPINs) that consist of a poly (lactic-co-glycolic acid) (PLGA) core, decorated by a dual membrane coating: a platelet membrane for precise adhesion to the damaged endothelium area and a stromal cell membrane to enhance receptor-ligand interactions and immune-evasiveness. This unique dual-membrane configuration synergistically reduces fibrosis and inflammation while promoting angiomyogenesis. This combination integrates the vascular injury targeting and immune-evasive properties of the nanoparticle, making this dual-membrane design a promising add-on intervention to augment post- percutaneous coronary intervention recovery, enhancing outcomes and offering potential improved cardiac repair.

Indexed as

Cardiac targetingHeart repairHybrid membrane coatingNanoparticles

Identifiers

PMID40688020
PMCPMC12272480

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.