Evidence map›Paper›PMID 40688238›Full record

SynthesisInternational journal of chronic obstructive pulmonary disease2025

Frailty in COPD: Clinical Impact, Diagnosis, Biomarkers, and Management Strategies.

Rakhima Azhimamatova, Rana Sherbaevna Salieva, Tazagul Bayishbecovna Zalova, Kunduzkhan Karimova, Dilshat S Karimova, Shekerbubu Anarbekovna Dyikanova, Roman Kalmatov, Urmatbek M Tynaliev

Registry-linked trialAbstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in International journal of chronic obstructive pulmonary disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07519603 (Frailty in Older Adults With Chronic Obstructive Pulmonary Disease), which is not on this map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07519603 narecruitingnot on this mapstarted 2026, after this paper: background citation

Frailty in Older Adults With Chronic Obstructive Pulmonary Disease (COPD) and Outcomes of the VIVIFRAIL Program

TypeinterventionalSponsorNational Geriatric HospitalRan2026 to 2027Enrolled80ConditionsChronic Obstructive Pulmonary Disease (COPD), FrailtyArmsVivifrail Exercise program, Usual Care Group
3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Rakhima AzhimamatovaInternational Medical Faculty, Osh State University, Osh City, Kyrgyz Republic.
Rana Sherbaevna SalievaInternational Medical Faculty, Osh State University, Osh City, Kyrgyz Republic.ORCID 0000-0002-6227-0394
Tazagul Bayishbecovna ZalovaInternational Medical Faculty, Osh State University, Osh City, Kyrgyz Republic.
Kunduzkhan KarimovaInstitute of Economy, Business and Management, Osh State University, Osh City, Kyrgyz Republic.
Dilshat S KarimovaInstitute of Economy, Business and Management, Osh State University, Osh City, Kyrgyz Republic.
Shekerbubu Anarbekovna DyikanovaInstitute of Economy, Business and Management, Osh State University, Osh City, Kyrgyz Republic.
Roman KalmatovInternational Medical Faculty, Osh State University, Osh City, Kyrgyz Republic.
Urmatbek M TynalievDirectorate for Research and Doctoral Education, Jusup Balasagyn Kyrgyz National University, Bishkek City, Kyrgyz Republic.ORCID 0000-0002-4433-0437

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Frailty is a complex clinical syndrome characterized by reduced physiological resilience and heightened susceptibility to external stressors, culminating in increased risks of functional decline, hospitalization, and mortality. In individuals with chronic obstructive pulmonary disease (COPD), frailty exacerbates disease burden and is closely linked to adverse outcomes, including increased exacerbation frequency, diminished quality of life, and poor prognosis. This review synthesizes current evidence on the interplay between frailty and COPD, emphasizing clinical implications, diagnostic frameworks, emerging biomarkers, and tailored management strategies. A systematic literature search was conducted across PubMed, Scopus, and Embase databases, employing key terms such as "frailty", "chronic obstructive pulmonary disease", "COPD", "frailty assessment", "biomarkers", and "frailty management in COPD". Inclusion criteria targeted English-language studies reporting original data with a direct focus on frailty in the context of COPD. By synthesizing multidimensional assessment strategies and potential therapeutic modalities, this review supports the development of precision-based interventions to reduce frailty and improve outcomes in patients with COPD.

Indexed as

Frail ElderlyFrailtyLungPulmonary Disease, Chronic ObstructiveAgedAged, 80 and overAge FactorsBiomarkersDisease ProgressionFunctional StatusGeriatric AssessmentHumansPredictive Value of TestsPrognosisQuality of LifeRisk FactorsBiomarkersCOPDfrailtyfrailty assessmentfrailty biomarkersfrailty scales

Identifiers

PMID40688238
PMCPMC12275923

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.