ArticleJournal of thoracic disease2025
Role of
Article in Journal of thoracic disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Esophageal squamous cell carcinoma (ESCC) is a leading cause of cancer-related mortality worldwide, with radiotherapy (RT) being a primary treatment modality. However, radioresistance-induced tumor recurrence significantly limits the effectiveness of RT. The aim of this study is to explore potential strategies to enhance radiosensitivity and reduce the risk of local recurrence in esophageal squamous cell carcinoma. Methods: Gene expression and clinical data of patients with advanced ESCC were analyzed using The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) databases. According to the expression profiles of 49 cuproptosis-related genes (CRGs), potential regulators of cuproptosis in ESCC were identified using unsupervised consensus clustering analysis, univariate Cox analysis, and least absolute shrinkage and selection operator (LASSO) regression. Western blotting, quantitative reverse transcription polymerase chain reaction (qRT-PCR) and intracellular copper measurement were used to explore the relationship between these genes and cuproptosis. Colony formation assay, Cell Counting Kit 8 (CCK-8) assay, 5-ethynyl-2'-deoxyuridine (EdU) assay, flow cytometry and immunofluorescence assay were performed to explore the efficacy of RT combined with cuproptosis inducers in ESCC. Results: Conclusions: Based on our findings
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.