Evidence map›Paper›PMID 40688306›Full record

ReviewJournal of thoracic disease2025

Addressing treatable traits in bronchiectasis through non-pharmacological therapies: a narrative review.

Annemarie L Lee, Arietta Spinou, Ashwin Basavaraj

Abstract readReview
In one paragraph

Review in Journal of thoracic disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. The importance of symptoms in bronchiectasis.European respiratory review : an official journal of the European Respiratory Society · 2026
    Review
  3. Physiology-Guided Selection of Hardware-Assisted Airway Clearance Techniques during Acute Exacerbations of Non-Cystic Fibrosis Bronchiectasis.Medical principles and practice : international journal of the Kuwait University, Health Science Centre · 2026
    Article
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Annemarie L LeeDepartment of Physiotherapy, School of Primary and Allied Health Care, Monash University, Frankston, Victoria, Australia.ORCID https://orcid.org/0000-0002-8631-0135
Arietta SpinouSchool of Life Course & Population Sciences, Faculty of Life Sciences and Medicine, King's College London, London, UK.ORCID https://orcid.org/0000-0002-3442-4739
Ashwin BasavarajDivision of Pulmonary, Critical Care and Sleep Medicine, New York University Grossman School of Medicine, New York, NY, USA.ORCID https://orcid.org/0000-0002-9904-6230

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background and Objective: Treatable traits in bronchiectasis have been classified as pulmonary, etiological, extra-pulmonary and behavioral or lifestyle factors. A range of non-pharmacological interventions may be applied to address these traits, with selected therapies applicable to multiple traits. The aim of this narrative review was to synthesize the evidence for non-pharmacological therapies through the lens of treatable traits for adults with bronchiectasis and highlight the clinical effects of these treatments. Methods: Electronic searches of PubMed and Medline using specific keywords were conducted. Articles underwent screening for relevance, with potential sources from review articles, systematic and scoping reviews, case series, prospective and retrospective studies, clinical practice guidelines and statements, and editorials in peer-reviewed journals. The data included were limited to English publications from 1980 to 2024. Key Content and Findings: Of those traits which fall under the pulmonary and etiology categories, treatment options include airway clearance therapy, adjuncts to airway clearance such as mucoactive agents, smoking cessation programs, non-invasive ventilation and oxygen therapy, including high flow nasal therapy. Extra-pulmonary traits that are amenable to non-pharmacological approaches included psychological symptoms, nutritional concerns, gastroesophageal reflux disease, rhinosinusitis and cardiovascular disease. Treatment options span from cognitive behavioral therapy and counselling, nutritional advice and supplements, lifestyle adjustments and nasal-sinus irrigation. Key behavioral or lifestyle traits are low treatment adherence, smoking and lack of exercise. These are addressed via education and self-management programs, smoking cessation, pulmonary rehabilitation and other forms of exercise or physical activity. Conclusions: A variety of non-pharmacological therapies may be applied to address treatable traits in those with bronchiectasis and adopting an integrated approach is important to optimize patient outcomes. Further studies could guide the implementation of non-pharmacological interventions for newly identified treatable traits in this population.

Indexed as

adherenceBronchiectasiscomorbiditiesphysiotherapytreatable traits

Identifiers

PMID40688306
PMCPMC12268470

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.