ArticleFood science & nutrition2025
Gallic Acid Improves Muscular Function Through Enhanced Myoblast Myogenesis in Mice.
Article in Food science & nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
7 citing papers in PubMed.
- Trial
- Developmental Cellular Programming: stage-specific architecting muscle and adipose tissues for high-quality meat production.Journal of animal science and biotechnology · 2026Review
- Lycopene Increases Skeletal Muscle Mass by Promoting Myoblast Differentiation.Food science & nutrition · 2026Article
- Article
- Effect of Alkyl Chain Length and Hydroxyl Substitution on the Antioxidant Activity of Gallic Acid Esters.Molecules (Basel, Switzerland) · 2026Article
- Article
- Gallic Acid Improves Muscular Function Through Enhanced Myoblast Myogenesis in Mice.Food science & nutrition · 2025Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Skeletal muscle health is crucial for maintaining physical function and metabolic homeostasis. This study investigated the effects of gallic acid, a naturally occurring phenolic compound, on myogenesis and muscle function. In vitro experiments using mouse primary myoblasts demonstrated that gallic acid (10 μg/mL) enhanced myogenic differentiation, evidenced by increased Myh3 protein expression (3.3-fold under growth conditions and 1.3-fold under differentiation conditions) and enhanced myotube formation in both conditions. In vivo studies were conducted using C57BL/6N mice fed either a control diet or a 0.2% gallic acid-supplemented diet for 8 weeks. While gallic acid supplementation did not affect body weight, food intake, or general metabolic parameters, it significantly increased soleus muscle mass (10.56 ± 1.35 mg vs. 8.28 ± 0.68 mg in controls). Furthermore, gallic acid-fed mice showed improved muscle function, with increased running distance (345.0 ± 28.8 m vs. 262.2 ± 58.6 m), extended time to exhaustion (24.2 ± 1.2 min vs. 20.1 ± 3.0 min), and enhanced grip strength (182.2 ± 19.4 N vs. 157.3 ± 11.5 N). These findings suggest that gallic acid could serve as a promising natural supplement for improving muscle function and exercise performance.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.