Evidence map›Paper›PMID 40688681›Full record

ReviewMaterials today. Bio2025

Advances in applications of low-dimensional piezoelectric materials in musculoskeletal system.

Lu Liu, Zhou Li, Tonghe Zhu, Yaying Sun, Jian Xu

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Materials today. Bio, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Lu LiuDepartment of Sports Medicine, Shanghai General Hospital, Shanghai Jiao Tong University, Shanghai, 200080, China.
Zhou LiDepartment of Sports Medicine, Shanghai General Hospital, Shanghai Jiao Tong University, Shanghai, 200080, China.
Tonghe ZhuMultidisciplinary Centre for Advanced Materials, Institute for Frontier Medical Technology, School of Chemistry and Chemical Engineering, Shanghai University of Engineering Science, Shanghai, 201620, China.
Yaying SunDepartment of Sports Medicine, Shanghai General Hospital, Shanghai Jiao Tong University, Shanghai, 200080, China.
Jian XuDepartment of Orthopaedics, Sports Medicine and Arthroscopy, Fuyang People's Hospital, Affiliated Hospital of Anhui Medical University, Anhui, 236000, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Musculoskeletal disorders pose a significant global health burden, necessitating innovative strategies for tissue repair and regeneration. Low-dimensional piezoelectric materials, characterized by their nanoscale dimensions and unique electromechanical coupling properties, have emerged as promising candidates for addressing these challenges. This review synthesizes advances in the application of low-dimensional piezoelectric materials (including 0D nanoparticles, 1D nanowires/nanofibers, and 2D nanosheets) across musculoskeletal tissues (including articular cartilage, bone, skeletal muscle and ligaments/tendons) in the past five years. Key strategies involve leveraging piezoelectric scaffolds, hydrogels, and nanocomposites to mimic native tissue microenvironments, promote cell differentiation and regeneration, enhance mechanotransduction, and provide self-powered electrical stimulation. Challenges such as material biocompatibility, long-term stability, and clinical scalability are discussed, alongside future directions like multimodal tissue regeneration and wearable piezoelectric devices for personalized medicine. This work underscores the transformative potential of low-dimensional piezoelectric materials in musculoskeletal regenerative medicine.

Indexed as

Low-dimensional nanomaterialsMusculoskeletal systemNanotechnologyPiezoelectric effectPiezoelectric materialsRegeneration

Identifiers

PMID40688681
PMCPMC12274872

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.