Evidence map›Paper›PMID 40688793›Full record

ArticleInternational journal of ophthalmology2025

Enhancement of retinal Müller glia's phagocytic activity against hard exudates by conbercept

Ying-Ying Zhu, Shi-Yue Qin, Hai Xie, Yin-Ping Liu, Xiao-Sa Li, Chao-Yang Zhang, Yan-Chun Zhang, Jing-Fa Zhang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of ophthalmology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Recent advances in the study of Conbercept for diabetic macular edema.International journal of retina and vitreous · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Ying-Ying ZhuDepartment of Ophthalmology, Yijishan Hospital, the First Affiliated Hospital of Wannan Medical College, Wuhu 241001, Anhui Province, China.
Shi-Yue QinDepartment of Ophthalmology, Taizhou People's Hospital, Taizhou 225300, Jiangsu Province, China.
Hai XieDepartment of Ophthalmology, Shanghai General Hospital (Shanghai First People's Hospital), Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
Yin-Ping LiuDepartment of Ophthalmology, Yijishan Hospital, the First Affiliated Hospital of Wannan Medical College, Wuhu 241001, Anhui Province, China.
Xiao-Sa LiDepartment of Ophthalmology, Shanghai General Hospital (Shanghai First People's Hospital), Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
Chao-Yang ZhangThe Primasia International Eye Research Institute of the Chinese University of Hong Kong (Shenzhen), Shenzhen 518000, Guangdong Province, China.
Yan-Chun ZhangDepartment of Ophthalmology, Shaanxi Eye Hospital, Xi'an People's Hospital (Xi'an Fourth Hospital), Affiliated People's Hospital of Northwest University, Xi'an 710000, Shaanxi Province, China.
Jing-Fa ZhangThe Primasia International Eye Research Institute of the Chinese University of Hong Kong (Shenzhen), Shenzhen 518000, Guangdong Province, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimTo investigate the effects and the underlying mechanism(s) of conbercept on the phagocytosis of hard exudates (HEs) by Müller glia in diabetic retinopathy (DR).

methodsTwenty-one eyes from 17 patients with diabetic macular edema (DME) underwent optical coherence tomography (OCT) imaging to examine the changes of HEs before and after intravitreal conbercept injection (IVC).

resultsThe area of HEs showed minimal change after the first IVC (1.39±1.41 to 1.38±1.3 mm

conclusionConbercept reduces HEs in DR by enhancing Müller glia phagocytosis possibly through activating PPARγ-CD36 axis, which is mediated by inhibition of VEGF signaling. Modulation of Müller glia phagocytic capacity might provide a novel therapeutic strategy to treat DR and DME.

Indexed as

conberceptMüller gliaoxidized low-density lipoproteinphagocytosisvascular endothelial growth factor

Identifiers

PMID40688793
PMCPMC12207301

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.